ID   UT-SCC-45
AC   CVCL_7852
SY   UTSCC45; University of Turku-Squamous Cell Carcinoma-45
DR   cancercelllines; CVCL_7852
DR   Wikidata; Q54992135
RX   PubMed=17312569;
RX   PubMed=29156801;
RX   PubMed=31541927;
RX   PubMed=33802339;
CC   Doubling time: 1.3 days (PubMed=29156801).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Gly72Arg (c.214G>A); ClinVar=VCV002164792; Zygosity=Homozygous (PubMed=31541927).
CC   Transformant: NCBI_TaxID; 10586; Human papillomavirus type 33 (HPV33).
CC   Omics: Deep exome analysis.
CC   Omics: Genome sequenced (low read coverage).
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
ST   Source(s): PubMed=29156801; PubMed=33802339
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 11,14
ST   D16S539: 9,13
ST   D18S51: 15
ST   D19S433: 14,15
ST   D21S11: 31.2
ST   D2S1338: 19
ST   D3S1358: 15
ST   D5S818: 11,12
ST   D7S820: 11,12
ST   D8S1179: 13,18
ST   FGA: 21,23
ST   TH01: 7,9.3
ST   TPOX: 11
ST   vWA: 18,20
DI   NCIt; C4041; Floor of mouth squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   76Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 13
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RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=31541927; DOI=10.1016/j.oraloncology.2019.09.004;
RA   van Harten A.M., Poell J.B., Buijze M., Brink A., Wells S.I.,
RA   Leemans C.R., Wolthuis R.M.F., Brakenhoff R.H.;
RT   "Characterization of a head and neck cancer-derived cell line panel
RT   confirms the distinct TP53-proficient copy number-silent subclass.";
RL   Oral Oncol. 98:53-61(2019).
//
RX   PubMed=33802339; DOI=10.3390/cancers13051069;
RA   Gottgens E.-L., Ansems M., Leenders W.P.J., Bussink J., Span P.N.;
RT   "Genotyping and characterization of HPV status, hypoxia, and
RT   radiosensitivity in 22 head and neck cancer cell lines.";
RL   Cancers (Basel) 13:1069.1-1069.12(2021).
//