Cellosaurus logo
expasy logo
Due to maintenance work, this service will be unavailable Tuesday 16 between 06:00 and 06:30 - CEST. Apologies for the inconvenience.

Cellosaurus UM-SCC-22B (CVCL_7732)

[Text version]
Cell line name UM-SCC-22B
Synonyms UM-SCC 22B; UMSCC-22B; UMSCC22B; UM-SCC22B; SCC22B; UMC-22b; UMC22b; UMC22B; UM-22B; University of Michigan-Squamous Cell Carcinoma-22B; 22B
Accession CVCL_7732
Resource Identification Initiative To cite this cell line use: UM-SCC-22B (RRID:CVCL_7732)
Comments Problematic cell line: Partially contaminated. At least one lab used a stock contaminated by T24 (Cellosaurus=CVCL_0554) (PubMed=29873307).
Part of: MD Anderson Cell Lines Project.
Doubling time: 34 +- 2 hours (PubMed=9139877).
Omics: Deep exome analysis.
Omics: Genome sequenced (low read coverage).
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.
Sequence variations
Disease Hypopharyngeal squamous cell carcinoma (NCIt: C4043)
Squamous cell carcinoma of the hypopharynx (ORDO: Orphanet_494547)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_7731 ! UM-SCC-22A
Sex of cell Female
Age at sampling 59Y
Category Cancer cell line
STR profile Source(s): Millipore=SCC077; PubMed=19760794; PubMed=21868764

Markers:
AmelogeninX
CSF1PO10
D3S135816
D5S81812
D7S8208,9
D8S117911,13
D13S3178,12
D16S5399,11
D18S5118
D21S1128
FGA22,24
Penta D13
Penta E12,18
TH016
TPOX8,11
vWA15,18

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=3335022
Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J., Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)

PubMed=1958593; DOI=10.1002/gcc.2870030406
Bradford C.R., Kimmel K.A., Van Dyke D.L., Worsham M.J., Tilley B.J., Burk D., del Rosario F., Lutz S., Tooley R., Hayashida D.J.S., Carey T.E.
11p deletions and breakpoints in squamous cell carcinoma: association with altered reactivity with the UM-E7 antibody.
Genes Chromosomes Cancer 3:272-282(1991)

DOI=10.1016/B978-0-12-333530-2.50007-1
Carey T.E.
Head and neck tumor cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994)

PubMed=8679156; DOI=10.1007/BF00178278
Koldovsky P., Haas I., Bier H., Ganzer U.
Immunohistochemical examination of 11 cell lines derived from human head and neck squamous cell carcinomas, their recurrences or metastases.
Eur. Arch. Otorhinolaryngol. 252:359-365(1995)

PubMed=9139877; DOI=10.1002/(SICI)1097-0215(19970502)71:3<410::AID-IJC18>3.0.CO;2-J
Welters M.J.P., Fichtinger-Schepman A.M.J., Baan R.A., Hermsen M.A.J.A., van der Vijgh W.J.F., Cloos J., Braakhuis B.J.M.
Relationship between the parameters cellular differentiation, doubling time and platinum accumulation and cisplatin sensitivity in a panel of head and neck cancer cell lines.
Int. J. Cancer 71:410-415(1997)

PubMed=10956384; DOI=10.1002/1097-0215(20000915)87:6<771::AID-IJC2>3.0.CO;2-V
Backus H.H.J., Pinedo H.M., Wouters D., Padron J.M., Molders N., van der Wilt C.L., van Groeningen C.J., Jansen G., Peters G.J.
Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates.
Int. J. Cancer 87:771-778(2000)

PubMed=15287027; DOI=10.1002/gcc.20066
Takebayashi S., Hickson A., Ogawa T., Jung K.-Y., Mineta H., Ueda Y., Grenman R., Fisher S.G., Carey T.E.
Loss of chromosome arm 18q with tumor progression in head and neck squamous cancer.
Genes Chromosomes Cancer 41:145-154(2004)

PubMed=15495191; DOI=10.1002/gcc.20119
Raschke S., Balz V., Efferth T., Schulz W.A., Florl A.R.
Homozygous deletions of CDKN2A caused by alternative mechanisms in various human cancer cell lines.
Genes Chromosomes Cancer 42:58-67(2005)

PubMed=16203773; DOI=10.1158/1078-0432.CCR-05-0378
Mandic R., Schamberger C.J., Muller J.F., Geyer M., Zhu L., Carey T.E., Grenman R., Dunne A.A., Werner J.A.
Reduced cisplatin sensitivity of head and neck squamous cell carcinoma cell lines correlates with mutations affecting the COOH-terminal nuclear localization signal of p53.
Clin. Cancer Res. 11:6845-6852(2005)

PubMed=17312569; DOI=10.1002/hed.20478
Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L., Koch W.M., Ferris R.L., Lai S.Y.
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=18006756; DOI=10.1158/1078-0432.CCR-07-1591
Friedman J., Nottingham L., Duggal P., Pernas F.G., Yan B., Yang X.-P., Chen Z., Van Waes C.
Deficient TP53 expression, function, and cisplatin sensitivity are restored by quinacrine in head and neck cancer.
Clin. Cancer Res. 13:6568-6578(2007)

PubMed=18487078; DOI=10.1016/j.oraloncology.2008.02.006
Hoffmann T.K., Sonkoly E., Hauser U., van Lierop A., Whiteside T.L., Klussmann J.P., Hafner D., Schuler P.J., Friebe-Hoffmann U., Scheckenbach K., Erjala K., Grenman R., Schipper J., Bier H., Balz V.
Alterations in the p53 pathway and their association with radio- and chemosensitivity in head and neck squamous cell carcinoma.
Oral Oncol. 44:1100-1109(2008)

PubMed=19760794; DOI=10.1002/hed.21198
Brenner J.C., Graham M.P., Kumar B., Saunders L.M., Kupfer R., Lyons R.H., Bradford C.R., Carey T.E.
Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines.
Head Neck 32:417-426(2010)

PubMed=20145189; DOI=10.1158/1940-6207.CAPR-09-0076
Chakravarti N., Kadara H., Yoon D.-J., Shay J.W., Myers J.N., Lotan D., Sonenberg N., Lotan R.
Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells.
Cancer Prev. Res. (Philadelphia) 3:331-338(2010)

PubMed=20947470; DOI=10.1186/2047-783X-15-8-337
Schuler P.J., Trellakis S., Greve J., Bas M.B., Bergmann C., Bolke E., Lehnerdt G.F., Mattheis S., Albers A.E., Brandau S., Lang S.K., Whiteside T.L., Bier H., Hoffmann T.K.
In vitro chemosensitivity of head and neck cancer cell lines.
Eur. J. Med. Res. 15:337-344(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=23613873; DOI=10.1371/journal.pone.0061555
Martens-de Kemp S.R., Dalm S.U., Wijnolts F.M.J., Brink A., Honeywell R.J., Peters G.J., Braakhuis B.J.M., Brakenhoff R.H.
DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells.
PLoS ONE 8:E61555-E61555(2013)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y., Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=29873307; DOI=10.1088/1361-6560/aacaba
Fru L.C., Adamson E.B., Campos D.D., Fain S.B., Jacques S.L., van der Kogel A.J., Nickel K.P., Song C., Kimple R.J., Kissick M.W.
Corrigendum: Potential role of the glycolytic oscillator in acute hypoxia in tumors (2015 Phys. Med. Biol. 60 9215).
Phys. Med. Biol. 63:139501-139501(2018)

PubMed=31541927; DOI=10.1016/j.oraloncology.2019.09.004
van Harten A.M., Poell J.B., Buijze M., Brink A., Wells S.I., Leemans C.R., Wolthuis R.M.F., Brakenhoff R.H.
Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass.
Oral Oncol. 98:53-61(2019)

Cross-references
Cell line collections (Providers) Millipore; SCC077
Cell line databases/resources cancercelllines; CVCL_7732
Chemistry resources ChEMBL-Cells; CHEMBL3307244
ChEMBL-Targets; CHEMBL612798
PubChem_Cell_line; CVCL_7732
Encyclopedic resources Wikidata; Q54990838
Polymorphism and mutation databases Cosmic; 932291
Cosmic; 948034
Cosmic; 1130358
Cosmic; 1483459
Cosmic; 2131862
Cosmic; 2513914
Cosmic; 2602598
IARC_TP53; 21637
IARC_TP53; 25909
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number34