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Cellosaurus UM-SCC-17B (CVCL_7725)

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Cell line name UM-SCC-17B
Synonyms UMSCC-17B; UMSCC17B; University of Michigan-Squamous Cell Carcinoma-17B
Accession CVCL_7725
Resource Identification Initiative To cite this cell line use: UM-SCC-17B (RRID:CVCL_7725)
Comments Part of: OPC-22 oral and pharyngeal cancer cell line panel.
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; RNAseq.
Omics: Variations; CNV analysis.
Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.
Sequence variations
Disease Laryngeal squamous cell carcinoma (NCIt: C4044)
Squamous cell carcinoma of the larynx (ORDO: Orphanet_494550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_5G90 ! UM-Ly(ebv)-17
CVCL_7724 ! UM-SCC-17A
Sex of cell Female
Age at sampling 48Y
Category Cancer cell line
STR profile Source(s): Millipore=SCC075; PubMed=19760794; PubMed=21868764; PubMed=25275298

Markers:
AmelogeninX
CSF1PO10,11
D3S135815,18
D5S81811
D7S82013
D8S117912,13
D13S31711,13
D16S53910,11
D18S5122
D21S1128
FGA20,22
Penta D10
Penta E5,19
TH016,8
TPOX10,11
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=6417595; DOI=10.1177/019459988309100503
Thomas E. Carey, Kathryn Anne Kimmel, Donald R. Schwartz, Diane E. Richter, Shan R. Baker, Charles J. Krause;
Antibodies to human squamous cell carcinoma.
Otolaryngol. Head Neck Surg. 91:482-491(1983)

PubMed=3855324; DOI=10.1288/00005537-198501000-00012
Shan R. Baker;
An in vivo model for squamous cell carcinoma of the head and neck.
Laryngoscope 95:43-56(1985)

PubMed=2790823
Thomas E. Carey, Daniel L. Van Dyke, Maria J. Worsham, Carol R. Bradford, V. Ramesh Babu, Donald R. Schwartz, Sandra Hsu, Shan R. Baker;
Characterization of human laryngeal primary and metastatic squamous cell carcinoma cell lines UM-SCC-17A and UM-SCC-17B.
Cancer Res. 49:6098-6107(1989)

PubMed=1851275; DOI=10.1177/019459989110400304
Carol R. Bradford, Susan E. Zacks, Elliot J. Androphy, Lucie Gregoire, Wayne D. Lancaster, Thomas E. Carey;
Human papillomavirus DNA sequences in cell lines derived from head and neck squamous cell carcinomas.
Otolaryngol. Head Neck Surg. 104:303-310(1991)

PubMed=1958593; DOI=10.1002/gcc.2870030406
Carol R. Bradford, Kathryn Anne Kimmel, Daniel L. Van Dyke, Maria J. Worsham, Barbara J. Tilley, David Burk, Fernando del Rosario, Stephen Lutz, Richard Tooley, Diana J.S. Hayashida, Thomas E. Carey;
11p deletions and breakpoints in squamous cell carcinoma: association with altered reactivity with the UM-E7 antibody.
Genes Chromosomes Cancer 3:272-282(1991)

DOI=10.1016/B978-0-12-333530-2.50007-1
Thomas E. Carey;
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=12884349; DOI=10.1002/hed.10274
Carol R. Bradford, Shao-Bo Zhu, Haruko Ogawa, Tetsuya Ogawa, Matthew Ubell, Ajita Narayan, Garfield Johnson, Gregory T. Wolf, Susan G. Fisher, Thomas E. Carey;
p53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines.
Head Neck 25:654-661(2003)

PubMed=15287027; DOI=10.1002/gcc.20066
Satoru Takebayashi, Arthur Hickson, Tetsuya Ogawa, Kwang-Yoon Jung, Hiroyuki Mineta, Yo Ueda, Reidar Grenman, Susan G. Fisher, Thomas E. Carey;
Loss of chromosome arm 18q with tumor progression in head and neck squamous cancer.
Genes Chromosomes Cancer 41:145-154(2004)

PubMed=16331601; DOI=10.1002/ijc.21514
Anja Muller, Eniko Sonkoly, Christine Eulert, Peter Arne Gerber, Robert Kubitza, Kerstin Schirlau, Petra Franken-Kunkel, Christopher Poremba, Carl Henry Snyderman, Lars-Oliver Klotz, Thomas Ruzicka ...Show all 16 authors... , Henning Bier, Albert Zlotnik, Theresa L. Whiteside, Bernhard Homey, Thomas K. Hoffmann; Show fewer authors
Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy.
Int. J. Cancer 118:2147-2157(2006)

PubMed=16785414; DOI=10.1001/archotol.132.6.668
Maria J. Worsham, Kang Mei Chen, Venkata Meduri, Anders O.H. Nygren, Abdellatif Errami, Jan P. Schouten, Michael S. Benninger;
Epigenetic events of disease progression in head and neck squamous cell carcinoma.
Arch. Otolaryngol. Head Neck Surg. 132:668-677(2006)

PubMed=17312569; DOI=10.1002/hed.20478
Charles J. Lin, Jennifer Rubin Grandis, Thomas E. Carey, Susanne M. Gollin, Theresa L. Whiteside, Wayne M. Koch, Robert Louis Ferris, Stephen Y. Lai;
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=18487078; DOI=10.1016/j.oraloncology.2008.02.006
Thomas K. Hoffmann, Eniko Sonkoly, Ulrich Hauser, Anke van Lierop, Theresa L. Whiteside, Jens Peter Klussmann, Dieter Hafner, Patrick J. Schuler, Ulrike Friebe-Hoffmann, Kathrin Scheckenbach, Kaisa Erjala ...Show all 15 authors... , Reidar Grenman, Jorg Schipper, Henning Bier, Vera Balz; Show fewer authors
Alterations in the p53 pathway and their association with radio- and chemosensitivity in head and neck squamous cell carcinoma.
Oral Oncol. 44:1100-1109(2008)

PubMed=19760794; DOI=10.1002/hed.21198; PMCID=PMC3292176
J. Chad Brenner, Martin P. Graham, Bhavna Kumar, Lindsay M. Saunders, Robbi Kupfer, Robert H. Lyons, Carol R. Bradford, Thomas E. Carey;
Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines.
Head Neck 32:417-426(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=25275298; DOI=10.18632/oncotarget.2417; PMCID=PMC4253406
Daniel Martin, Martin C. Abba, Alfredo Alberto Molinolo, Lynn Vitale-Cross, Zhi-Yong Wang, Moraima Zaida, Naomi C. Delic, Yardena Samuels, J. Guy Lyons, J. Silvio Gutkind;
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.
Oncotarget 5:8906-8923(2014)

PubMed=26754630; DOI=10.1186/s13046-016-0284-4; PMCID=PMC4709939
Hiroshi Hyakusoku, Daisuke Sano, Hideaki Takahashi, Takashi Hatano, Yasuhiro Isono, Shoko Shimada, Yusuke Ito, Jeffrey N. Myers, Nobuhiko Oridate;
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Nene N. Kalu, Tuhina Mazumdar, Shao-Hua Peng, Li Shen, Vaishnav Sambandam, Xia-Yu Rao, Yuan-Xin Xi, Le-Rong Li, Yuan Qi, Frederico O. Gleber-Netto, Ameeta Patel ...Show all 16 authors... , Jing Wang, Mitchell J. Frederick, Jeffrey N. Myers, Curtis R. Pickering, Faye M. Johnson; Show fewer authors
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=31090975; DOI=10.1002/hed.25803; PMCID=PMC6692232
Jacqueline E. Mann, Aditi Kulkarni, Andrew C. Birkeland, Judy Kafelghazal, Julia Eisenberg, Brittany M. Jewell, Megan L. Ludwig, Matthew Edward Spector, Hui Jiang, Thomas E. Carey, J. Chad Brenner;
The molecular landscape of the University of Michigan laryngeal squamous cell carcinoma cell line panel.
Head Neck 41:3114-3124(2019)

Cross-references
Cell line collections (Providers) Millipore; SCC075
Cell line databases/resources cancercelllines; CVCL_7725
Anatomy/cell type resources BTO; BTO_0002711
Encyclopedic resources Wikidata; Q54990828
Gene expression databases GEO; GSM3631269
Polymorphism and mutation databases Cosmic; 948032
Cosmic; 2296307
Cosmic; 2602596
IARC_TP53; 21101
Progenetix; CVCL_7725
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number31