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Cellosaurus UM-SCC-17A (CVCL_7724)

[Text version]
Cell line name UM-SCC-17A
Synonyms UM-SCC 17A; UMSCC-17A; UMSCC17A; UM-SCC17A; SCC17A; University of Michigan-Squamous Cell Carcinoma-17A
Accession CVCL_7724
Resource Identification Initiative To cite this cell line use: UM-SCC-17A (RRID:CVCL_7724)
Comments Part of: MD Anderson Cell Lines Project.
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Larynx; UBERON=UBERON_0001737.
Sequence variations
Disease Laryngeal squamous cell carcinoma (NCIt: C4044)
Squamous cell carcinoma of the larynx (ORDO: Orphanet_494550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_9T71 (UM-SCC-17As)
Originate from same individual CVCL_5G90 ! UM-Ly(ebv)-17
CVCL_7725 ! UM-SCC-17B
Sex of cell Female
Age at sampling 48Y
Category Cancer cell line
STR profile Source(s): Millipore=SCC074; PubMed=19760794; PubMed=21868764

Markers:
AmelogeninX
CSF1PO10,11
D3S135815,18
D5S81811
D7S82013
D8S117912,13
D13S31711,13
D16S53910,11
D18S5117,22
D21S1128
FGA20,22
Penta D10
Penta E5,19
TH016,8
TPOX10,11
vWA14,17

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=6417595; DOI=10.1177/019459988309100503
Thomas E. Carey, Kathryn Anne Kimmel, Donald R. Schwartz, Diane E. Richter, Shan R. Baker, Charles J. Krause;
Antibodies to human squamous cell carcinoma.
Otolaryngol. Head Neck Surg. 91:482-491(1983)

PubMed=3855324; DOI=10.1288/00005537-198501000-00012
Shan R. Baker;
An in vivo model for squamous cell carcinoma of the head and neck.
Laryngoscope 95:43-56(1985)

PubMed=2790823
Thomas E. Carey, Daniel L. Van Dyke, Maria J. Worsham, Carol R. Bradford, V. Ramesh Babu, Donald R. Schwartz, Sandra Hsu, Shan R. Baker;
Characterization of human laryngeal primary and metastatic squamous cell carcinoma cell lines UM-SCC-17A and UM-SCC-17B.
Cancer Res. 49:6098-6107(1989)

PubMed=1851275; DOI=10.1177/019459989110400304
Carol R. Bradford, Susan E. Zacks, Elliot J. Androphy, Lucie Gregoire, Wayne D. Lancaster, Thomas E. Carey;
Human papillomavirus DNA sequences in cell lines derived from head and neck squamous cell carcinomas.
Otolaryngol. Head Neck Surg. 104:303-310(1991)

PubMed=1958593; DOI=10.1002/gcc.2870030406
Carol R. Bradford, Kathryn Anne Kimmel, Daniel L. Van Dyke, Maria J. Worsham, Barbara J. Tilley, David Burk, Fernando del Rosario, Stephen Lutz, Richard Tooley, Diana J.S. Hayashida, Thomas E. Carey;
11p deletions and breakpoints in squamous cell carcinoma: association with altered reactivity with the UM-E7 antibody.
Genes Chromosomes Cancer 3:272-282(1991)

DOI=10.1016/B978-0-12-333530-2.50007-1
Thomas E. Carey;
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=8679156; DOI=10.1007/BF00178278
Pavel Koldovsky, Ida Haas, Henning Bier, Uwe Ganzer;
Immunohistochemical examination of 11 cell lines derived from human head and neck squamous cell carcinomas, their recurrences or metastases.
Eur. Arch. Otorhinolaryngol. 252:359-365(1995)

PubMed=15287027; DOI=10.1002/gcc.20066
Satoru Takebayashi, Arthur Hickson, Tetsuya Ogawa, Kwang-Yoon Jung, Hiroyuki Mineta, Yo Ueda, Reidar Grenman, Susan G. Fisher, Thomas E. Carey;
Loss of chromosome arm 18q with tumor progression in head and neck squamous cancer.
Genes Chromosomes Cancer 41:145-154(2004)

PubMed=15495191; DOI=10.1002/gcc.20119
Sascha Raschke, Vera Balz, Thomas Efferth, Wolfgang A. Schulz, Andrea R. Florl;
Homozygous deletions of CDKN2A caused by alternative mechanisms in various human cancer cell lines.
Genes Chromosomes Cancer 42:58-67(2005)

PubMed=16331601; DOI=10.1002/ijc.21514
Anja Muller, Eniko Sonkoly, Christine Eulert, Peter Arne Gerber, Robert Kubitza, Kerstin Schirlau, Petra Franken-Kunkel, Christopher Poremba, Carl Henry Snyderman, Lars-Oliver Klotz, Thomas Ruzicka ...Show all 16 authors... , Henning Bier, Albert Zlotnik, Theresa L. Whiteside, Bernhard Homey, Thomas K. Hoffmann; Show fewer authors
Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy.
Int. J. Cancer 118:2147-2157(2006)

PubMed=16785414; DOI=10.1001/archotol.132.6.668
Maria J. Worsham, Kang Mei Chen, Venkata Meduri, Anders O.H. Nygren, Abdellatif Errami, Jan P. Schouten, Michael S. Benninger;
Epigenetic events of disease progression in head and neck squamous cell carcinoma.
Arch. Otolaryngol. Head Neck Surg. 132:668-677(2006)

PubMed=17312569; DOI=10.1002/hed.20478
Charles J. Lin, Jennifer Rubin Grandis, Thomas E. Carey, Susanne M. Gollin, Theresa L. Whiteside, Wayne M. Koch, Robert Louis Ferris, Stephen Y. Lai;
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=18487078; DOI=10.1016/j.oraloncology.2008.02.006
Thomas K. Hoffmann, Eniko Sonkoly, Ulrich Hauser, Anke van Lierop, Theresa L. Whiteside, Jens Peter Klussmann, Dieter Hafner, Patrick J. Schuler, Ulrike Friebe-Hoffmann, Kathrin Scheckenbach, Kaisa Erjala ...Show all 15 authors... , Reidar Grenman, Jorg Schipper, Henning Bier, Vera Balz; Show fewer authors
Alterations in the p53 pathway and their association with radio- and chemosensitivity in head and neck squamous cell carcinoma.
Oral Oncol. 44:1100-1109(2008)

PubMed=19760794; DOI=10.1002/hed.21198; PMCID=PMC3292176
J. Chad Brenner, Martin P. Graham, Bhavna Kumar, Lindsay M. Saunders, Robbi Kupfer, Robert H. Lyons, Carol R. Bradford, Thomas E. Carey;
Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines.
Head Neck 32:417-426(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=26754630; DOI=10.1186/s13046-016-0284-4; PMCID=PMC4709939
Hiroshi Hyakusoku, Daisuke Sano, Hideaki Takahashi, Takashi Hatano, Yasuhiro Isono, Shoko Shimada, Yusuke Ito, Jeffrey N. Myers, Nobuhiko Oridate;
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Nene N. Kalu, Tuhina Mazumdar, Shao-Hua Peng, Li Shen, Vaishnav Sambandam, Xia-Yu Rao, Yuan-Xin Xi, Le-Rong Li, Yuan Qi, Frederico O. Gleber-Netto, Ameeta Patel ...Show all 16 authors... , Jing Wang, Mitchell J. Frederick, Jeffrey N. Myers, Curtis R. Pickering, Faye M. Johnson; Show fewer authors
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=32574978; DOI=10.1016/j.tranon.2020.100808; PMCID=PMC7317296
Thankam S. Nair, Trey B. Thomas, Lucy Yang, Bala Naveen Kakaraparthi, Anna C. Morris, Alanna M. Clark, Lora Perry Campredon, Andrew F. Brouwer, Marisa C. Eisenberg, Rafael Meza, Thomas E. Carey;
Characteristics of head and neck squamous cell carcinoma cell lines reflect human tumor biology independent of primary etiologies and HPV status.
Transl. Oncol. 13:100808.1-100808.9(2020)

Cross-references
Cell line collections (Providers) Millipore; SCC074
Anatomy/cell type resources BTO; BTO_0004022
Encyclopedic resources Wikidata; Q54990826
Polymorphism and mutation databases Cosmic; 932290
Cosmic; 948031
Cosmic; 1130355
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27