Cellosaurus logo
expasy logo

Cellosaurus UM-SCC-14C (CVCL_7721)

[Text version]
Cell line name UM-SCC-14C
Synonyms UM-SCC 14C; UMSCC-14C; UMSCC14C; UM-SCC14C; University of Michigan-Squamous Cell Carcinoma-14C; 14C
Accession CVCL_7721
Resource Identification Initiative To cite this cell line use: UM-SCC-14C (RRID:CVCL_7721)
Comments Population: Caucasian.
Doubling time: 27 +- 4 hours (PubMed=9139877).
Omics: Genomics; Whole genome sequencing; Low read coverage.
Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
Sequence variations
Disease Floor of mouth squamous cell carcinoma (NCIt: C4041)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_7719 ! UM-SCC-14A
CVCL_7720 ! UM-SCC-14B
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): CLS=300370; PubMed=19760794

Markers:
AmelogeninX
CSF1PO10
D3S135815
D5S81811,14
D7S8209,10
D8S11798,13
D13S31712
D16S53912
D18S5115
D21S1129
FGA20,21
Penta D12,16
Penta E7
TH016,8
TPOX8
vWA14,18

Run an STR similarity search on this cell line
Publications

PubMed=3335022
Michael C. Alley, Dominic A. Scudiero, Anne Monks, Miriam L. Hursey, Maciej J. Czerwinski, Donald L. Fine, Betty Jane Abbott, Joseph G. Mayo, Robert H. Shoemaker, Michael R. Boyd;
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)

PubMed=8679156; DOI=10.1007/BF00178278
Pavel Koldovsky, Ida Haas, Henning Bier, Uwe Ganzer;
Immunohistochemical examination of 11 cell lines derived from human head and neck squamous cell carcinomas, their recurrences or metastases.
Eur. Arch. Otorhinolaryngol. 252:359-365(1995)

PubMed=9041179
Christopher J. Frank, Kenneth Donald McClatchey, Kenneth O. Devaney, Thomas E. Carey;
Evidence that loss of chromosome 18q is associated with tumor progression.
Cancer Res. 57:824-827(1997)

PubMed=9139877; DOI=10.1002/(SICI)1097-0215(19970502)71:3<410::AID-IJC18>3.0.CO;2-J
Marij J.P. Welters, Anne Marie Josephine Fichtinger-Schepman, Robert A. Baan, Mario A.J.A. Hermsen, Wim J.F. van der Vijgh, Jacqueline Cloos, Boudewijn J.M. Braakhuis;
Relationship between the parameters cellular differentiation, doubling time and platinum accumulation and cisplatin sensitivity in a panel of head and neck cancer cell lines.
Int. J. Cancer 71:410-415(1997)

PubMed=10956384; DOI=10.1002/1097-0215(20000915)87:6<771::AID-IJC2>3.0.CO;2-V
Harold H.J. Backus, Herbert Michael Pinedo, Dorine Wouters, Jose Manuel Padron, N. Molders, Clasina L. van der Wilt, Cornelis J. van Groeningen, Gerrit Jansen, Godefridus Johannes Peters;
Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates.
Int. J. Cancer 87:771-778(2000)

PubMed=15287027; DOI=10.1002/gcc.20066
Satoru Takebayashi, Arthur Hickson, Tetsuya Ogawa, Kwang-Yoon Jung, Hiroyuki Mineta, Yo Ueda, Reidar Grenman, Susan G. Fisher, Thomas E. Carey;
Loss of chromosome arm 18q with tumor progression in head and neck squamous cancer.
Genes Chromosomes Cancer 41:145-154(2004)

PubMed=15495191; DOI=10.1002/gcc.20119
Sascha Raschke, Vera Balz, Thomas Efferth, Wolfgang A. Schulz, Andrea R. Florl;
Homozygous deletions of CDKN2A caused by alternative mechanisms in various human cancer cell lines.
Genes Chromosomes Cancer 42:58-67(2005)

PubMed=17312569; DOI=10.1002/hed.20478
Charles J. Lin, Jennifer Rubin Grandis, Thomas E. Carey, Susanne M. Gollin, Theresa L. Whiteside, Wayne M. Koch, Robert Louis Ferris, Stephen Y. Lai;
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=18487078; DOI=10.1016/j.oraloncology.2008.02.006
Thomas K. Hoffmann, Eniko Sonkoly, Ulrich Hauser, Anke van Lierop, Theresa L. Whiteside, Jens Peter Klussmann, Dieter Hafner, Patrick J. Schuler, Ulrike Friebe-Hoffmann, Kathrin Scheckenbach, Kaisa Erjala ...Show all 15 authors... , Reidar Grenman, Jorg Schipper, Henning Bier, Vera Balz; Show fewer authors
Alterations in the p53 pathway and their association with radio- and chemosensitivity in head and neck squamous cell carcinoma.
Oral Oncol. 44:1100-1109(2008)

PubMed=19760794; DOI=10.1002/hed.21198; PMCID=PMC3292176
J. Chad Brenner, Martin P. Graham, Bhavna Kumar, Lindsay M. Saunders, Robbi Kupfer, Robert H. Lyons, Carol R. Bradford, Thomas E. Carey;
Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines.
Head Neck 32:417-426(2010)

PubMed=20947470; DOI=10.1186/2047-783X-15-8-337; PMCID=PMC3458702
Patrick J. Schuler, Sokratis Trellakis, Jens Greve, M. Barnabas Bas, Carsten Bergmann, Edwin Bolke, Goetz Frederik Lehnerdt, Stefan Mattheis, Andreas E. Albers, Sven Brandau, Susanne Kate Lang ...Show all 14 authors... , Theresa L. Whiteside, Henning Bier, Thomas K. Hoffmann; Show fewer authors
In vitro chemosensitivity of head and neck cancer cell lines.
Eur. J. Med. Res. 15:337-344(2010)

PubMed=23613873; DOI=10.1371/journal.pone.0061555; PMCID=PMC3629194
Sanne R. Martens-de Kemp, Simone U. Dalm, Fiona M.J. Wijnolts, Arjen Brink, Richard J. Honeywell, Godefridus Johannes Peters, Boudewijn J.M. Braakhuis, Ruud H. Brakenhoff;
DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells.
PLoS ONE 8:e61555.1-e61555.9(2013)

PubMed=26122845; DOI=10.1158/0008-5472.CAN-15-0528
Chantal Stoepker, Najim Ameziane, Petra van der Lelij, Irsan E. Kooi, Anneke B. Oostra, Martin A. Rooimans, Saskia E. van Mil, Arjen Brink, Ralf Dietrich, Jesper A. Balk, Bauke Ylstra ...Show all 14 authors... , Hans Joenje, Stephan M. Feller, Ruud H. Brakenhoff; Show fewer authors
Defects in the Fanconi anemia pathway and chromatid cohesion in head and neck cancer.
Cancer Res. 75:3543-3553(2015)

PubMed=31541927; DOI=10.1016/j.oraloncology.2019.09.004; PMCID=PMC7372097
Anne M. van Harten, Jos B. Poell, Marijke Buijze, Arjen Brink, Susanne I. Wells, C. Rene Leemans, Rob M.F. Wolthuis, Ruud H. Brakenhoff;
Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass.
Oral Oncol. 98:53-61(2019)

Cross-references
Cell line collections (Providers) CLS; 300370 - Discontinued
Cell line databases/resources cancercelllines; CVCL_7721
Encyclopedic resources Wikidata; Q54990813
Polymorphism and mutation databases Cosmic; 932289
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number26