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Cellosaurus UM-SCC-14A (CVCL_7719)

[Text version]
Cell line name UM-SCC-14A
Synonyms UM-SCC 14A; UMSCC-14A; UMSCC14A; University of Michigan-Squamous Cell Carcinoma-14A
Accession CVCL_7719
Resource Identification Initiative To cite this cell line use: UM-SCC-14A (RRID:CVCL_7719)
Comments Population: Caucasian.
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing; Low read coverage.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; RNAseq.
Omics: Variations; CNV analysis.
Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
Sequence variations
Disease Floor of mouth squamous cell carcinoma (NCIt: C4041)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_7720 ! UM-SCC-14B
CVCL_7721 ! UM-SCC-14C
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): PubMed=19760794; PubMed=21868764

Markers:
AmelogeninX
CSF1PO10
D3S135815
D5S81811,14
D7S8209,10
D8S11798,13
D13S31712
D16S53911,12
D18S5115
D21S1129
FGA20,21
TH016,8
vWA14,18

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Publications

PubMed=3855324; DOI=10.1288/00005537-198501000-00012
Shan R. Baker;
An in vivo model for squamous cell carcinoma of the head and neck.
Laryngoscope 95:43-56(1985)

DOI=10.1016/B978-0-12-333530-2.50007-1
Thomas E. Carey;
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=8679156; DOI=10.1007/BF00178278
Pavel Koldovsky, Ida Haas, Henning Bier, Uwe Ganzer;
Immunohistochemical examination of 11 cell lines derived from human head and neck squamous cell carcinomas, their recurrences or metastases.
Eur. Arch. Otorhinolaryngol. 252:359-365(1995)

PubMed=8725545; DOI=10.3109/00016489609137854
Kirsi Pekkola-Heino, Kristina Servomaa, Anne Kiuru, Reidar Grenman;
Increased radiosensitivity is associated with p53 mutations in cell lines derived from oral cavity carcinoma.
Acta Oto-Laryngol. 116:341-344(1996)

PubMed=8782485; DOI=10.1046/j.1365-2184.1996.01009.x
Kristina Servomaa, Anne Kiuru, Reidar Grenman, Kirsi Pekkola-Heino, Jaakko O. Pulkkinen, Tapio Rytomaa;
p53 mutations associated with increased sensitivity to ionizing radiation in human head and neck cancer cell lines.
Cell Prolif. 29:219-230(1996)

PubMed=9041179
Christopher J. Frank, Kenneth Donald McClatchey, Kenneth O. Devaney, Thomas E. Carey;
Evidence that loss of chromosome 18q is associated with tumor progression.
Cancer Res. 57:824-827(1997)

PubMed=12884349; DOI=10.1002/hed.10274
Carol R. Bradford, Shao-Bo Zhu, Haruko Ogawa, Tetsuya Ogawa, Matthew Ubell, Ajita Narayan, Garfield Johnson, Gregory T. Wolf, Susan G. Fisher, Thomas E. Carey;
p53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines.
Head Neck 25:654-661(2003)

PubMed=15287027; DOI=10.1002/gcc.20066
Satoru Takebayashi, Arthur Hickson, Tetsuya Ogawa, Kwang-Yoon Jung, Hiroyuki Mineta, Yo Ueda, Reidar Grenman, Susan G. Fisher, Thomas E. Carey;
Loss of chromosome arm 18q with tumor progression in head and neck squamous cancer.
Genes Chromosomes Cancer 41:145-154(2004)

PubMed=17312569; DOI=10.1002/hed.20478
Charles J. Lin, Jennifer Rubin Grandis, Thomas E. Carey, Susanne M. Gollin, Theresa L. Whiteside, Wayne M. Koch, Robert Louis Ferris, Stephen Y. Lai;
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=18487078; DOI=10.1016/j.oraloncology.2008.02.006
Thomas K. Hoffmann, Eniko Sonkoly, Ulrich Hauser, Anke van Lierop, Theresa L. Whiteside, Jens Peter Klussmann, Dieter Hafner, Patrick J. Schuler, Ulrike Friebe-Hoffmann, Kathrin Scheckenbach, Kaisa Erjala ...Show all 15 authors... , Reidar Grenman, Jorg Schipper, Henning Bier, Vera Balz; Show fewer authors
Alterations in the p53 pathway and their association with radio- and chemosensitivity in head and neck squamous cell carcinoma.
Oral Oncol. 44:1100-1109(2008)

PubMed=19760794; DOI=10.1002/hed.21198; PMCID=PMC3292176
J. Chad Brenner, Martin P. Graham, Bhavna Kumar, Lindsay M. Saunders, Robbi Kupfer, Robert H. Lyons, Carol R. Bradford, Thomas E. Carey;
Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines.
Head Neck 32:417-426(2010)

PubMed=20947470; DOI=10.1186/2047-783X-15-8-337; PMCID=PMC3458702
Patrick J. Schuler, Sokratis Trellakis, Jens Greve, M. Barnabas Bas, Carsten Bergmann, Edwin Bolke, Goetz Frederik Lehnerdt, Stefan Mattheis, Andreas E. Albers, Sven Brandau, Susanne Kate Lang ...Show all 14 authors... , Theresa L. Whiteside, Henning Bier, Thomas K. Hoffmann; Show fewer authors
In vitro chemosensitivity of head and neck cancer cell lines.
Eur. J. Med. Res. 15:337-344(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=23613873; DOI=10.1371/journal.pone.0061555; PMCID=PMC3629194
Sanne R. Martens-de Kemp, Simone U. Dalm, Fiona M.J. Wijnolts, Arjen Brink, Richard J. Honeywell, Godefridus Johannes Peters, Boudewijn J.M. Braakhuis, Ruud H. Brakenhoff;
DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells.
PLoS ONE 8:e61555.1-e61555.9(2013)

PubMed=26122845; DOI=10.1158/0008-5472.CAN-15-0528
Chantal Stoepker, Najim Ameziane, Petra van der Lelij, Irsan E. Kooi, Anneke B. Oostra, Martin A. Rooimans, Saskia E. van Mil, Arjen Brink, Ralf Dietrich, Jesper A. Balk, Bauke Ylstra ...Show all 14 authors... , Hans Joenje, Stephan M. Feller, Ruud H. Brakenhoff; Show fewer authors
Defects in the Fanconi anemia pathway and chromatid cohesion in head and neck cancer.
Cancer Res. 75:3543-3553(2015)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Nene N. Kalu, Tuhina Mazumdar, Shao-Hua Peng, Li Shen, Vaishnav Sambandam, Xia-Yu Rao, Yuan-Xin Xi, Le-Rong Li, Yuan Qi, Frederico O. Gleber-Netto, Ameeta Patel ...Show all 16 authors... , Jing Wang, Mitchell J. Frederick, Jeffrey N. Myers, Curtis R. Pickering, Faye M. Johnson; Show fewer authors
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=30527230; DOI=10.1016/j.oraloncology.2018.10.031; PMCID=PMC6349383
Megan L. Ludwig, Aditi Kulkarni, Andrew C. Birkeland, Nicole L. Michmerhuizen, Susan K. Foltin, Jacqueline E. Mann, Rebecca C. Hoesli, Samantha N. Devenport, Brittany M. Jewell, Andrew G. Shuman, Matthew Edward Spector ...Show all 14 authors... , Thomas E. Carey, Hui Jiang, J. Chad Brenner; Show fewer authors
The genomic landscape of UM-SCC oral cavity squamous cell carcinoma cell lines.
Oral Oncol. 87:144-151(2018)

PubMed=31541927; DOI=10.1016/j.oraloncology.2019.09.004; PMCID=PMC7372097
Anne M. van Harten, Jos B. Poell, Marijke Buijze, Arjen Brink, Susanne I. Wells, C. Rene Leemans, Rob M.F. Wolthuis, Ruud H. Brakenhoff;
Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass.
Oral Oncol. 98:53-61(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7719
Anatomy/cell type resources BTO; BTO_0003140
Chemistry resources ChEMBL-Cells; CHEMBL3707162
ChEMBL-Targets; CHEMBL3707164
PubChem_Cell_line; CVCL_7719
Encyclopedic resources Wikidata; Q54990811
Gene expression databases GEO; GSM3631268
Polymorphism and mutation databases Cosmic; 948029
Cosmic; 1483458
IARC_TP53; 11062
IARC_TP53; 18879
Progenetix; CVCL_7719
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number28