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Cellosaurus ECC-1 (CVCL_7260)

[Text version]
Cell line name ECC-1
Synonyms ECC1; EnCa1
Accession CVCL_7260
Resource Identification Initiative To cite this cell line use: ECC-1 (RRID:CVCL_7260)
Comments Problematic cell line: Contaminated. Shown to be a Ishikawa 3-H-12 derivative (PubMed=22710073).
Part of: ENCODE project common cell types; tier 3.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00460.
Population: Japanese.
Omics: Array-based CGH.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
Sequence variations
  • Mutation; HGNC; 8979; PIK3R1; Simple; p.Leu570Pro (c.1709T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9177; POLE; Simple; p.Pro102Ser (c.304C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9177; POLE; Simple; p.Asn751fs (c.2252delA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Glu288fs*3 (c.863delA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Thr319fs*1 (c.950_953delTACT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Asp49His (c.145G>C); ClinVar=VCV000135948; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Met246Val (c.736A>G); ClinVar=VCV000100815; Zygosity=Heterozygous (from parent cell line).
Disease Endometrial adenocarcinoma (NCIt: C7359)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D199 (Ishikawa 3-H-12)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2923; PubMed=22710073; PubMed=25877200; PubMed=33174010

Markers:
AmelogeninX
CSF1PO11,12
D2S133820
D3S135816,17
D5S81810,11
D7S8209,10
D8S117913,16
D13S3179,12
D16S5399
D18S5112,19
D19S43312.2,14
D21S1128
FGA21
Penta D10,11
Penta E11,19.1
TH019,10
TPOX8
vWA14,17

Run an STR similarity search on this cell line
Web pages http://genome.ucsc.edu/ENCODE/protocols/cell/human/ECC1_Myers_protocol.pdf
https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=10478797; DOI=10.1007/s11626-999-0025-5
Ricci M.S., Toscano D.G., Toscano W.A. Jr.
ECC-1 human endometrial cells as a model system to study dioxin disruption of steroid hormone function.
In Vitro Cell. Dev. Biol. Anim. 35:183-189(1999)

PubMed=16707768; DOI=10.1095/biolreprod.106.051870
Mo B., Vendrov A.E., Palomino W.A., DuPont B.R., Apparao K.B.C., Lessey B.A.
ECC-1 cells: a well-differentiated steroid-responsive endometrial cell line with characteristics of luminal epithelium.
Biol. Reprod. 75:387-394(2006)

PubMed=20218740; DOI=10.1177/153303461000900207
Wang Y.-M., Yang D., Cogdell D., Hu L.-M., Xue F.-X., Broaddus R., Zhang W.
Genomic characterization of gene copy-number aberrations in endometrial carcinoma cell lines derived from endometrioid-type endometrial adenocarcinoma.
Technol. Cancer Res. Treat. 9:179-189(2010)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017
Korch C.T., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

PubMed=23325432; DOI=10.1101/gr.147942.112
Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M.
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=33174010; DOI=10.3892/ijo.2020.5139
Devor E.J., Gonzalez-Bosquet J., Thiel K.W., Leslie K.K.
Genomic characterization of five commonly used endometrial cancer cell lines.
Int. J. Oncol. 57:1348-1357(2020)

Cross-references
Cell line collections (Providers) ATCC; CRL-2923 - Discontinued
Cell line databases/resources CLO; CLO_0037231
cancercelllines; CVCL_7260
Lonza; 1319
Anatomy/cell type resources BTO; BTO:0005365
Biological sample resources BioSample; SAMN03151801
BioSample; SAMN03472871
ENCODE; ENCBS034DOC
ENCODE; ENCBS159ITB
ENCODE; ENCBS222DWG
ENCODE; ENCBS312UTV
ENCODE; ENCBS336PJO
ENCODE; ENCBS347ANJ
ENCODE; ENCBS624SHM
ENCODE; ENCBS670ZEX
ENCODE; ENCBS731RSG
ENCODE; ENCBS743VIZ
ENCODE; ENCBS758FSP
ENCODE; ENCBS767JJY
ENCODE; ENCBS862NRL
ENCODE; ENCBS896YZO
Encyclopedic resources Wikidata; Q54831921
Experimental variables resources EFO; EFO_0005231
Gene expression databases GEO; GSM843495
GEO; GSM843496
GEO; GSM923422
GEO; GSM923423
GEO; GSM923426
GEO; GSM923427
GEO; GSM1008597
GEO; GSM1008574
Polymorphism and mutation databases Cosmic; 1102375
Cosmic; 1576451
Cosmic; 1622895
Cosmic; 2030461
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number29