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Cellosaurus Sav-BL (CVCL_7210)

[Text version]
Cell line name Sav-BL
Synonyms Sav
Accession CVCL_7210
Resource Identification Initiative To cite this cell line use: Sav-BL (RRID:CVCL_7210)
Comments Population: African.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Cell type: B-cell; CL=CL_0000236.
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category Cancer cell line
Publications

PubMed=12219084; DOI=10.1038/nm758
Kelly G.L., Bell A.I., Rickinson A.B.
Epstein-Barr virus-associated Burkitt lymphomagenesis selects for downregulation of the nuclear antigen EBNA2.
Nat. Med. 8:1098-1104(2002)

PubMed=16051863; DOI=10.1128/JVI.79.16.10709-10717.2005; PMCID=PMC1182620
Kelly G.L., Milner A.E., Tierney R.J., Croom-Carter D.S.G., Altmann M., Hammerschmidt W., Bell A.I., Rickinson A.B.
Epstein-Barr virus nuclear antigen 2 (EBNA2) gene deletion is consistently linked with EBNA3A, -3B, and -3C expression in Burkitt's lymphoma cells and with increased resistance to apoptosis.
J. Virol. 79:10709-10717(2005)

PubMed=21088132; DOI=10.1182/blood-2010-05-285791; PMCID=PMC3056644
Vereide D.T., Sugden B.
Lymphomas differ in their dependence on Epstein-Barr virus.
Blood 117:1977-1985(2011)

PubMed=28960205; DOI=10.1038/cdd.2017.150; PMCID=PMC5762840
Fitzsimmons L., Boyce A.J., Wei W.-B., Chang C., Croom-Carter D.S.G., Tierney R.J., Herold M.J., Bell A.I., Strasser A., Kelly G.L., Rowe M.
Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells.
Cell Death Differ. 25:241-254(2018)

Cross-references
Encyclopedic resources Wikidata; Q54952144
Gene expression databases GEO; GSM1604065
GEO; GSM1604066
GEO; GSM1604067
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number10