ID   Sav-BL
AC   CVCL_7210
SY   Sav
DR   GEO; GSM1604065
DR   GEO; GSM1604066
DR   GEO; GSM1604067
DR   Wikidata; Q54952144
RX   PubMed=12219084;
RX   PubMed=16051863;
RX   PubMed=21088132;
RX   PubMed=28960205;
CC   Population: African.
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 10
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RX   PubMed=12219084; DOI=10.1038/nm758;
RA   Kelly G.L., Bell A.I., Rickinson A.B.;
RT   "Epstein-Barr virus-associated Burkitt lymphomagenesis selects for
RT   downregulation of the nuclear antigen EBNA2.";
RL   Nat. Med. 8:1098-1104(2002).
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RX   PubMed=16051863; DOI=10.1128/JVI.79.16.10709-10717.2005; PMCID=PMC1182620;
RA   Kelly G.L., Milner A.E., Tierney R.J., Croom-Carter D.S.G.,
RA   Altmann M., Hammerschmidt W., Bell A.I., Rickinson A.B.;
RT   "Epstein-Barr virus nuclear antigen 2 (EBNA2) gene deletion is
RT   consistently linked with EBNA3A, -3B, and -3C expression in Burkitt's
RT   lymphoma cells and with increased resistance to apoptosis.";
RL   J. Virol. 79:10709-10717(2005).
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RX   PubMed=21088132; DOI=10.1182/blood-2010-05-285791; PMCID=PMC3056644;
RA   Vereide D.T., Sugden B.;
RT   "Lymphomas differ in their dependence on Epstein-Barr virus.";
RL   Blood 117:1977-1985(2011).
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RX   PubMed=28960205; DOI=10.1038/cdd.2017.150; PMCID=PMC5762840;
RA   Fitzsimmons L., Boyce A.J., Wei W.-B., Chang C., Croom-Carter D.S.G.,
RA   Tierney R.J., Herold M.J., Bell A.I., Strasser A., Kelly G.L.,
RA   Rowe M.;
RT   "Coordinated repression of BIM and PUMA by Epstein-Barr virus latent
RT   genes maintains the survival of Burkitt lymphoma cells.";
RL   Cell Death Differ. 25:241-254(2018).
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