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Cellosaurus Mutu-1 (CVCL_7202)

[Text version]
Cell line name Mutu-1
Synonyms MUTU-1; Mutu 1; Mutu1; MUTU1; MUTU-BL group I; Mutu I; Mutu-I; MutuI; MUTU-BL; MUTU BL; Mutu.BL; Mutu; Mutuku
Accession CVCL_7202
Resource Identification Initiative To cite this cell line use: Mutu-1 (RRID:CVCL_7202)
Comments Population: African; Kenyan.
Virology: Contains a complete EBV genome (strain Mutu) which has been sequenced (PubMed=23152513; PubMed=25787276).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; 7553; MYC; Simple; p.Thr73Asn (c.218C>A); Zygosity=Unspecified (PubMed=8108117).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_ZY05 (Mutu-)CVCL_7203 (Mutu-3)
Originate from same individual CVCL_ZU67 ! Mutu-LCL
Sex of cell Male
Category Cancer cell line
STR profile Source(s): JCRB=JCRB1811

Markers:
AmelogeninX,Y
CSF1PO10
D5S81812,14
D7S8208,10
D13S31712,13
D16S53913
TH017
TPOX8,11
vWA15,17

Run an STR similarity search on this cell line
Web pages https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-4.html
Publications

PubMed=2898508; DOI=10.1084/jem.167.6.1811; PMCID=PMC2189677
Gregory C.D., Murray R.J., Edwards C.F., Rickinson A.B.
Downregulation of cell adhesion molecules LFA-3 and ICAM-1 in Epstein-Barr virus-positive Burkitt's lymphoma underlies tumor cell escape from virus-specific T cell surveillance.
J. Exp. Med. 167:1811-1824(1988)

PubMed=2165133; DOI=10.1099/0022-1317-71-7-1481
Gregory C.D., Rowe M., Rickinson A.B.
Different Epstein-Barr virus-B cell interactions in phenotypically distinct clones of a Burkitt's lymphoma cell line.
J. Gen. Virol. 71:1481-1495(1990)

PubMed=1356511; DOI=10.1182/blood.V80.7.1781.1781
Gaidano G., Hauptschein R.S., Parsa N.Z., Offit K., Rao P.H., Lenoir G.M., Knowles D.M., Chaganti R.S.K., Dalla-Favera R.
Deletions involving two distinct regions of 6q in B-cell non-Hodgkin lymphoma.
Blood 80:1781-1787(1992)

PubMed=8108117
Albert T., Urlbauer B., Kohlhuber F., Hammersen B., Eick D.
Ongoing mutations in the N-terminal domain of c-Myc affect transactivation in Burkitt's lymphoma cell lines.
Oncogene 9:759-763(1994)

PubMed=9473234; DOI=10.1182/blood.V91.5.1680
Klangby U., Okan I., Magnusson K.P., Wendland M., Lind P., Wiman K.G.
p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma.
Blood 91:1680-1687(1998)

PubMed=23152513; DOI=10.1128/JVI.02517-12; PMCID=PMC3554088
Lin Z., Wang X., Strong M.J., Concha M., Baddoo M., Xu G.-R., Baribault C., Fewell C., Hulme W., Hedges D., Taylor C.M., Flemington E.K.
Whole-genome sequencing of the Akata and Mutu Epstein-Barr virus strains.
J. Virol. 87:1172-1182(2013)

PubMed=25787276; DOI=10.1128/JVI.03614-14; PMCID=PMC4442510
Palser A.L., Grayson N.E., White R.E., Corton C., Correia S., Ba Abdullah M.M., Watson S.J., Cotten M., Arrand J.R., Murray P.G., Allday M.J., Rickinson A.B., Young L.S., Farrell P.J., Kellam P.
Genome diversity of Epstein-Barr virus from multiple tumor types and normal infection.
J. Virol. 89:5222-5237(2015)

PubMed=28960205; DOI=10.1038/cdd.2017.150; PMCID=PMC5762840
Fitzsimmons L., Boyce A.J., Wei W.-B., Chang C., Croom-Carter D.S.G., Tierney R.J., Herold M.J., Bell A.I., Strasser A., Kelly G.L., Rowe M.
Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells.
Cell Death Differ. 25:241-254(2018)

Cross-references
Cell line collections (Providers) JCRB; JCRB1811
Cell line databases/resources Lonza; 1378
Encyclopedic resources Wikidata; Q54907095
Gene expression databases GEO; GSM1604059
GEO; GSM1604060
GEO; GSM1604061
Polymorphism and mutation databases Cosmic; 931129
Cosmic; 1517666
Cosmic; 2804853
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number18