ID   Mutu-1
AC   CVCL_7202
SY   MUTU-1; Mutu 1; Mutu1; MUTU1; MUTU-BL group I; Mutu I; Mutu-I; MutuI; MUTU-BL; MUTU BL; Mutu.BL; Mutu; Mutuku
DR   Cosmic; 931129
DR   Cosmic; 1517666
DR   Cosmic; 2804853
DR   GEO; GSM1604059
DR   GEO; GSM1604060
DR   GEO; GSM1604061
DR   JCRB; JCRB1811
DR   Lonza; 1378
DR   Wikidata; Q54907095
RX   PubMed=1356511;
RX   PubMed=2165133;
RX   PubMed=2898508;
RX   PubMed=8108117;
RX   PubMed=9473234;
RX   PubMed=23152513;
RX   PubMed=25787276;
RX   PubMed=28960205;
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-4.html
CC   Population: African; Kenyan.
CC   Virology: Contains a complete EBV genome (strain Mutu) which has been sequenced (PubMed=23152513; PubMed=25787276).
CC   Sequence variation: Mutation; HGNC; 7553; MYC; Simple; p.Thr73Asn (c.218C>A); Zygosity=Unspecified (PubMed=8108117).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Cell type: B-cell; CL=CL_0000236.
ST   Source(s): JCRB=JCRB1811
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 12,13
ST   D16S539: 13
ST   D5S818: 12,14
ST   D7S820: 8,10
ST   TH01: 7
ST   TPOX: 8,11
ST   vWA: 15,17
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_ZU67 ! Mutu-LCL
SX   Male
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 18
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RX   PubMed=1356511; DOI=10.1182/blood.V80.7.1781.1781;
RA   Gaidano G., Hauptschein R.S., Parsa N.Z., Offit K., Rao P.H.,
RA   Lenoir G.M., Knowles D.M., Chaganti R.S.K., Dalla-Favera R.;
RT   "Deletions involving two distinct regions of 6q in B-cell non-Hodgkin
RT   lymphoma.";
RL   Blood 80:1781-1787(1992).
//
RX   PubMed=2165133; DOI=10.1099/0022-1317-71-7-1481;
RA   Gregory C.D., Rowe M., Rickinson A.B.;
RT   "Different Epstein-Barr virus-B cell interactions in phenotypically
RT   distinct clones of a Burkitt's lymphoma cell line.";
RL   J. Gen. Virol. 71:1481-1495(1990).
//
RX   PubMed=2898508; DOI=10.1084/jem.167.6.1811; PMCID=PMC2189677;
RA   Gregory C.D., Murray R.J., Edwards C.F., Rickinson A.B.;
RT   "Downregulation of cell adhesion molecules LFA-3 and ICAM-1 in
RT   Epstein-Barr virus-positive Burkitt's lymphoma underlies tumor cell
RT   escape from virus-specific T cell surveillance.";
RL   J. Exp. Med. 167:1811-1824(1988).
//
RX   PubMed=8108117;
RA   Albert T., Urlbauer B., Kohlhuber F., Hammersen B., Eick D.;
RT   "Ongoing mutations in the N-terminal domain of c-Myc affect
RT   transactivation in Burkitt's lymphoma cell lines.";
RL   Oncogene 9:759-763(1994).
//
RX   PubMed=9473234; DOI=10.1182/blood.V91.5.1680;
RA   Klangby U., Okan I., Magnusson K.P., Wendland M., Lind P., Wiman K.G.;
RT   "p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a
RT   mRNA and protein expression in Burkitt's lymphoma.";
RL   Blood 91:1680-1687(1998).
//
RX   PubMed=23152513; DOI=10.1128/JVI.02517-12; PMCID=PMC3554088;
RA   Lin Z., Wang X., Strong M.J., Concha M., Baddoo M., Xu G.-R.,
RA   Baribault C., Fewell C., Hulme W., Hedges D., Taylor C.M.,
RA   Flemington E.K.;
RT   "Whole-genome sequencing of the Akata and Mutu Epstein-Barr virus
RT   strains.";
RL   J. Virol. 87:1172-1182(2013).
//
RX   PubMed=25787276; DOI=10.1128/JVI.03614-14; PMCID=PMC4442510;
RA   Palser A.L., Grayson N.E., White R.E., Corton C., Correia S.,
RA   Ba Abdullah M.M., Watson S.J., Cotten M., Arrand J.R., Murray P.G.,
RA   Allday M.J., Rickinson A.B., Young L.S., Farrell P.J., Kellam P.;
RT   "Genome diversity of Epstein-Barr virus from multiple tumor types and
RT   normal infection.";
RL   J. Virol. 89:5222-5237(2015).
//
RX   PubMed=28960205; DOI=10.1038/cdd.2017.150; PMCID=PMC5762840;
RA   Fitzsimmons L., Boyce A.J., Wei W.-B., Chang C., Croom-Carter D.S.G.,
RA   Tierney R.J., Herold M.J., Bell A.I., Strasser A., Kelly G.L.,
RA   Rowe M.;
RT   "Coordinated repression of BIM and PUMA by Epstein-Barr virus latent
RT   genes maintains the survival of Burkitt lymphoma cells.";
RL   Cell Death Differ. 25:241-254(2018).
//