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Cellosaurus TTC-547 (CVCL_7152)

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Cell line name TTC-547
Synonyms TTC547; TC-547; TU-547
Accession CVCL_7152
Resource Identification Initiative To cite this cell line use: TTC-547 (RRID:CVCL_7152)
Comments Part of: MD Anderson Cell Lines Project.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Pelvis; UBERON=UBERON_0002355.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=25010205).
  • Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (PubMed=25010205).
Disease Alveolar rhabdomyosarcoma (NCIt: C3749)
Alveolar rhabdomyosarcoma (ORDO: Orphanet_99756)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 13Y
Category Cancer cell line
STR profile Source(s): PubMed=25010205

Markers:
AmelogeninX
CSF1PO10,12
D2S133818,24
D3S135816,17
D5S81812
D7S82011
D8S117911,13
D13S31711,13
D16S53912
D18S5113,19
D19S43312,13
D21S1131,33.2
FGA21,24
TH019.3
TPOX8,11
vWA14,17

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

CLPUB00569
Paul S. Dickman, Maria G. Tsokos, Timothy J. Triche;
Biology of rhabdomyosarcoma: cell culture, xenografts, and animal models.
(In book chapter) Rhabdomyosarcoma and related tumors in children and adolescents; Maurer, Harold M. & Ruymann, Frederick Beeman & Pochedly, Carl Eugene (eds.); pp.49-88; CRC Press; Boca Raton; USA (1991)

PubMed=7882340
Poul H.B. Sorensen, Hiroyuki Shimada, Xian F. Liu, Jerian F. Lim, Gilles Thomas, Timothy J. Triche;
Biphenotypic sarcomas with myogenic and neural differentiation express the Ewing's sarcoma EWS/FLI1 fusion gene.
Cancer Res. 55:1385-1392(1995)

PubMed=23665679; DOI=10.1038/onc.2013.129
Elizabeth I. Sokolowski, Claire B. Turina, Ken Kikuchi, David M. Langenau, Charles Keller;
Proof-of-concept rare cancers in drug development: the case for rhabdomyosarcoma.
Oncogene 33:1877-1889(2014)

PubMed=25010205; DOI=10.1371/journal.pgen.1004475; PMCID=PMC4091782
Andrew S. Brohl, David A. Solomon, Wendy Chang, Jian-Jun Wang, Young Song, Sivasish Sindiri, Rajesh Patidar, Laura Hurd, Li Chen, Jack F. Shern, Hong-Ling Liao ...Show all 26 authors... , Xin-Yu Wen, Julia Gerard, Jung-Sik Kim, Jose Antonio Lopez Guerrero, Isidro Machado, Daniel H. Wai, Piero Picci, Timothy J. Triche, Andrew E. Horvai, Markku Martti Miettinen, Jun S. Wei, Daniel Catchpoole, Antonio Llombart-Bosch, Todd A. Waldman, Javed Khan; Show fewer authors
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:e1004475.1-e1004475.13(2014)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Encyclopedic resources Wikidata; Q54973242
Polymorphism and mutation databases Cosmic; 1091072
Cosmic; 2228247
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number21