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Cellosaurus SQ-20B (CVCL_7138)

[Text version]
Cell line name SQ-20B
Synonyms SQ20B; SQ20-B
Accession CVCL_7138
Resource Identification Initiative To cite this cell line use: SQ-20B (RRID:CVCL_7138)
Comments Omics: Transcriptomics; Microarray.
Misspelling: SQ2013; Cosmic=1530760.
Derived from site: In situ; Larynx; UBERON=UBERON_0001737.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Unspecified; Note=Splice acceptor mutation (PubMed=8339273).
Disease Laryngeal squamous cell carcinoma (NCIt: C4044)
Squamous cell carcinoma of the larynx (ORDO: Orphanet_494550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_EI29 (ER-SQ20B)CVCL_D774 (SQD9)CVCL_D775 (SQG6)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=3458227; DOI=10.1073/pnas.83.8.2684; PMCID=PMC323364
Ralph R. Weichselbaum, William K. Dahlberg, Michael A. Beckett, Theodore Karrison, Daniel Miller, John Clark, Thomas J. Ervin;
Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients.
Proc. Natl. Acad. Sci. U.S.A. 83:2684-2688(1986)

PubMed=3616625; DOI=10.1126/science.3616625
Usha Nakhasi Kasid, Andrea M.A. Pfeifer, Ralph R. Weichselbaum, Anatoly Dritschilo, George E. Mark 3rd;
The raf oncogene is associated with a radiation-resistant human laryngeal cancer.
Science 237:1039-1041(1987)

PubMed=3182330; DOI=10.1016/0360-3016(88)90125-3
Jeffrey L. Schwartz, Jacob Rotmensch, Susan Giovanazzi, Marvin B. Cohen, Ralph R. Weichselbaum;
Faster repair of DNA double-strand breaks in radioresistant human tumor cells.
Int. J. Radiat. Oncol. Biol. Phys. 15:907-912(1988)

PubMed=3417487; DOI=10.1016/0360-3016(88)90297-0
Ralph R. Weichselbaum, Michael A. Beckett, Jeffrey L. Schwartz, Anatoly Dritschilo;
Radioresistant tumor cells are present in head and neck carcinomas that recur after radiotherapy.
Int. J. Radiat. Oncol. Biol. Phys. 15:575-579(1988)

PubMed=2466340; DOI=10.1126/science.2466340
Usha Nakhasi Kasid, Andrea M.A. Pfeifer, Terrence Brennan, Michael A. Beckett, Ralph R. Weichselbaum, Anatoly Dritschilo, George E. Mark 3rd;
Effect of antisense c-raf-1 on tumorigenicity and radiation sensitivity of a human squamous carcinoma.
Science 243:1354-1356(1989)

PubMed=2573646; DOI=10.1080/09553008914551731
Ralph R. Weichselbaum, Jacob Rotmensch, Sijsan Ahmed-Swan, Michael A. Beckett;
Radiobiological characterization of 53 human tumor cell lines.
Int. J. Radiat. Biol. 56:553-560(1989)

PubMed=2380097; DOI=10.1016/0360-3016(90)90136-8
Dennis E. Hallahan, Michael A. Beckett, Donald William Kufe, Ralph R. Weichselbaum;
The interaction between recombinant human tumor necrosis factor and radiation in 13 human tumor cell lines.
Int. J. Radiat. Oncol. Biol. Phys. 19:69-74(1990)

PubMed=1423286
Mira Jung, Vicente Notario, Anatoly Dritschilo;
Mutations in the p53 gene in radiation-sensitive and -resistant human squamous carcinoma cells.
Cancer Res. 52:6390-6393(1992)

PubMed=1574572; DOI=10.2307/3578273
Edward J. Dunphy, Michael A. Beckett, Lawrence H. Thompson, Ralph R. Weichselbaum;
Expression of the polymorphic human DNA repair gene XRCC1 does not correlate with radiosensitivity in the cells of human head and neck tumor cell lines.
Radiat. Res. 130:166-170(1992)

PubMed=8339273
David G. Brachman, Michael A. Beckett, Deborah Graves, Daniel Haraf, Everett E. Vokes, Ralph R. Weichselbaum;
p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines.
Cancer Res. 53:3667-3669(1993)

DOI=10.1016/B978-0-12-333530-2.50007-1
Thomas E. Carey;
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=7938462; DOI=10.2307/3578897
Monique F.M.A. Smeets, Els H.M. Dahmen-Mooren, Abdel Hady Ali Abdel-Wahab, Harry Bartelink, Adrian C. Begg;
Differential repair of radiation-induced DNA damage in cells of human squamous cell carcinoma and the effect of caffeine and cysteamine on induction and repair of DNA double-strand breaks.
Radiat. Res. 140:153-160(1994)

PubMed=17312569; DOI=10.1002/hed.20478
Charles J. Lin, Jennifer Rubin Grandis, Thomas E. Carey, Susanne M. Gollin, Theresa L. Whiteside, Wayne M. Koch, Robert Louis Ferris, Stephen Y. Lai;
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=17848307; DOI=10.1016/j.ijrobp.2007.04.082
Wendell Gray Yarbrough, Amy Whigham, Brandee Brown, Michael Roach, Robbert J.C. Slebos;
Phosphoinositide kinase-3 status associated with presence or absence of human papillomavirus in head and neck squamous cell carcinomas.
Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007)

PubMed=25888065; DOI=10.1016/j.molonc.2015.03.008; PMCID=PMC4523436
Aditya Stanam, Laurie Love-Homan, Tisha S. Joseph, Madelyn Espinosa-Cotton, Andrean L. Simons;
Upregulated interleukin-6 expression contributes to erlotinib resistance in head and neck squamous cell carcinoma.
Mol. Oncol. 9:1371-1383(2015)

Cross-references
Cell line collections (Providers) Millipore; SCC287
Cell line databases/resources cancercelllines; CVCL_7138
TOKU-E; 4134
Chemistry resources ChEMBL-Cells; CHEMBL3307460
ChEMBL-Targets; CHEMBL614939
PubChem_Cell_line; CVCL_7138
Encyclopedic resources Wikidata; Q54955598
Gene expression databases GEO; GSM1524316
GEO; GSM1524317
GEO; GSM1524318
Polymorphism and mutation databases Cosmic; 1122674
Cosmic; 1530760
Cosmic; 1530761
IARC_TP53; 6406
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27