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Cellosaurus SMS-KCNR (CVCL_7134)

[Text version]
Cell line name SMS-KCNR
Synonyms sms-KCNR; SMSKCNR; KCNR; KCN-R
Accession CVCL_7134
Resource Identification Initiative To cite this cell line use: SMS-KCNR (RRID:CVCL_7134)
Comments Doubling time: ~72 hours (PubMed=3456456).
Omics: Transcriptomics; Microarray.
Omics: Variations; Array-based CGH.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_AQ28 ! SMS-KCL
CVCL_7133 ! SMS-KCN
Sex of cell Male
Age at sampling 11M
Category Cancer cell line
STR profile Source(s): COG

Markers:
AmelogeninX,Y
CSF1PO10
D2S133817,22
D3S135814,15
D5S81811
D7S8209,11
D8S117913,14
D13S31712,13
D16S53910,11
D18S5115,19
D19S43314,15
D21S1130,31.2
FGA19,22
TH019.3
TPOX11
vWA17,18

Run an STR similarity search on this cell line
Web pages Provider; CCR; -; https://www.cccells.org/dl/NB_Data_Sheets/SMS-KCNR_Cell_Line_Data_Sheet_COGcell_org.pdf
Publications

PubMed=7037175
Charles Patrick Reynolds, Debra A. Reynolds, Eugene Philip Frenkel, R. Graham Smith;
Selective toxicity of 6-hydroxydopamine and ascorbate for human neuroblastoma in vitro: a model for clearing marrow prior to autologous transplant.
Cancer Res. 42:1331-1336(1982)

DOI=10.1016/B978-0-12-008304-6.50015-4
June Lee Biedler, Marian B. Meyers, Barbara A. Spengler;
Homogeneously staining regions and double minute chromosomes, prevalent cytogenetic abnormalities of human neuroblastoma cells.
(In book chapter) Advances in cellular neurobiology, Vol. 4; Fedoroff, Sergey & Hertz, Leif (eds.); pp.267-307; Academic Press; New York; USA (1983)

PubMed=3456456; DOI=10.1093/jnci/76.3.375
Charles Patrick Reynolds, June Lee Biedler, Barbara A. Spengler, Debra A. Reynolds, Robert A. Ross, Eugene Philip Frenkel, R. Graham Smith;
Characterization of human neuroblastoma cell lines established before and after therapy.
J. Natl. Cancer Inst. 76:375-387(1986)

DOI=10.1016/B978-0-12-333530-2.50006-X
Mark A. Israel, Carol Jeanne Thiele;
Tumor cell lines of the peripheral nervous system.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.43-78; Academic Press; New York; USA (1994)

PubMed=7838528
Ngan Ching Cheng, Nadine Van Roy, Alvin Chan, Mabel Beitsma, Andries Westerveld, Frank Speleman, Rogier Versteeg;
Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.
Oncogene 10:291-297(1995)

PubMed=8665486; DOI=10.1016/0304-3835(96)04250-4
Mitchell B. Diccianni, Lan S. Chau, Ayse Batova, Thai Q. Vu, Alice Lin-Tsing Yu;
The p16 and p18 tumor suppressor genes in neuroblastoma: implications for drug resistance.
Cancer Lett. 104:183-192(1996)

PubMed=9283597; DOI=10.1016/S0165-4608(96)00362-7
Nadine Van Roy, Anna Jauch, Mireille Van Gele, Genevieve Laureys, Rogier Versteeg, Anne De Paepe, Thomas Cremer, Frank Speleman;
Comparative genomic hybridization analysis of human neuroblastomas: detection of distal 1p deletions and further molecular genetic characterization of neuroblastoma cell lines.
Cancer Genet. Cytogenet. 97:135-142(1997)

DOI=10.1007/0-306-46872-7_2
Carol Jeanne Thiele;
Neuroblastoma.
(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999)

PubMed=11507071
Nino Keshelava, Juan J. Zuo, Ping Chen, Sitara N. Waidyaratne, Marian C. Luna, Charles Joseph Gomer, Timothy J. Triche, Charles Patrick Reynolds;
Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines.
Cancer Res. 61:6185-6193(2001)

PubMed=12702577
Fumiko Saito-Ohara, Issei Imoto, Jun Inoue, Hajime Hosoi, Akira Nakagawara, Tohru Sugimoto, Johji Inazawa;
PPM1D is a potential target for 17q gain in neuroblastoma.
Cancer Res. 63:1876-1883(2003)

PubMed=15390183; DOI=10.1002/gcc.20096
Sigrun Gebauer, Alice Lin-Tsing Yu, Motoko Omura-Minamisawa, Ayse Batova, Mitchell B. Diccianni;
Expression profiles and clinical relationships of ID2, CDKN1B, and CDKN2A in primary neuroblastoma.
Genes Chromosomes Cancer 41:297-308(2004)

PubMed=15892104; DOI=10.1002/gcc.20198
Yael P. Mosse, Joel Greshock, Adam A. Margolin, Tara Naylor, Kristina A. Cole, Deepa Khazi, George Hii, Cynthia Winter, Syed Shahzad, Muhammad Usman Asziz, Jaclyn A. Biegel ...Show all 13 authors... , Barbara L. Weber, John Matthew Maris; Show fewer authors
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Genes Chromosomes Cancer 43:390-403(2005)

PubMed=16822308; DOI=10.1186/1471-2407-6-177; PMCID=PMC1533846
Vincent Dam, Brian T. Morgan, Pavel Mazanek, Michael D. Hogarty;
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177.1-177.10(2006)

PubMed=18923523; DOI=10.1038/nature07398
Isabelle Janoueix-Lerosey, Delphine Lequin, Laurence Brugieres, Agnes Ribeiro, Loic de Pontual, Valerie Combaret, Virginie Raynal, Alain Puisieux, Gudrun Schleiermacher, Gaelle Pierron, Dominique Valteau-Couanet ...Show all 16 authors... , Thierry Frebourg, Jean Michon, Stanislas Lyonnet, Jeanne Amiel, Olivier Delattre; Show fewer authors
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma.
Nature 455:967-970(2008)

PubMed=20655465; DOI=10.1016/j.cell.2010.06.004; PMCID=PMC2913027
Michael Holzel, Si-Dong Huang, Jan Koster, Ingrid Ora, Arjan Lakeman, Huib Nicolaas Caron, Wouter Nijkamp, Jing Xie, Tom Callens, Shahab Asgharzadeh, Robert C. Seeger ...Show all 14 authors... , Ludwine M. Messiaen, Rogier Versteeg, Rene Bernards; Show fewer authors
NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.
Cell 142:218-229(2010)

PubMed=22213050; DOI=10.1002/ijc.27415; PMCID=PMC3757132
Joanna E. Gawecka, Dirk Geerts, Jan Koster, Maisel J. Caliva, Florian J. Sulzmaier, John Opoku-Ansah, Randal K. Wada, Andre S. Bachmann, Joe W. Ramos;
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)

PubMed=24792489; DOI=10.1007/s11060-014-1456-8
Ahsan S. Farooqi, Rebecca A. Dagg, L. Mi Rim Choi, Jerry W. Shay, Charles Patrick Reynolds, Loretta M.S. Lau;
Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations.
J. Neurooncol. 119:17-26(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7134
CGH-DB; 9100-4
Encyclopedic resources Wikidata; Q54954992
Gene expression databases GEO; GSM692866
Polymorphism and mutation databases Cosmic; 848941
Cosmic; 922673
Cosmic; 1019950
Cosmic; 1109112
Cosmic; 1153804
Cosmic; 1167413
Cosmic; 1518067
Cosmic; 1526651
Cosmic; 2239460
Cosmic; 2393633
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27