Cellosaurus logo
expasy logo

Cellosaurus SMS-KCN (CVCL_7133)

[Text version]
Cell line name SMS-KCN
Synonyms KCN; SMS-KCNs; NB07C
Accession CVCL_7133
Resource Identification Initiative To cite this cell line use: SMS-KCN (RRID:CVCL_7133)
Comments Characteristics: Substrate-adherent type (S-type) (PubMed=15720811).
Doubling time: ~109 hours (PubMed=3456456).
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Proteomics; PTM; Tyrosine phosphorylation.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Sequence variations
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_RK69 (SMS-KCN-69n)CVCL_WM95 (SMS-KCN-A)CVCL_WZ30 (SMS-KCN11s)
CVCL_WZ31 (SMS-KCN5n)
Originate from same individual CVCL_AQ28 ! SMS-KCL
CVCL_7134 ! SMS-KCNR
Sex of cell Male
Age at sampling 11M
Category Cancer cell line
STR profile Source(s): COG

Markers:
AmelogeninX,Y
CSF1PO10
D2S133817,22
D3S135814,15
D5S81811
D7S8209,11
D8S117913,14
D13S31712,13
D16S53910,11
D18S5115,19
D19S43314,15
D21S1130,31.2
FGA19,22
TH019.3
TPOX11
vWA17,18

Run an STR similarity search on this cell line
Web pages Provider; CCR; -; https://www.cccells.org/dl/NB_Data_Sheets/SMS-KCN_Cell_Line_Data_Sheet_COGcell_org.pdf
Publications

PubMed=7037175
Charles Patrick Reynolds, Debra A. Reynolds, Eugene Philip Frenkel, R. Graham Smith;
Selective toxicity of 6-hydroxydopamine and ascorbate for human neuroblastoma in vitro: a model for clearing marrow prior to autologous transplant.
Cancer Res. 42:1331-1336(1982)

DOI=10.1016/B978-0-12-008304-6.50015-4
June Lee Biedler, Marian B. Meyers, Barbara A. Spengler;
Homogeneously staining regions and double minute chromosomes, prevalent cytogenetic abnormalities of human neuroblastoma cells.
(In book chapter) Advances in cellular neurobiology, Vol. 4; Fedoroff, Sergey & Hertz, Leif (eds.); pp.267-307; Academic Press; New York; USA (1983)

PubMed=3456456; DOI=10.1093/jnci/76.3.375
Charles Patrick Reynolds, June Lee Biedler, Barbara A. Spengler, Debra A. Reynolds, Robert A. Ross, Eugene Philip Frenkel, R. Graham Smith;
Characterization of human neuroblastoma cell lines established before and after therapy.
J. Natl. Cancer Inst. 76:375-387(1986)

PubMed=2535691
Valentina C. Ciccarone, Barbara A. Spengler, Marian B. Meyers, June Lee Biedler, Robert A. Ross;
Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages.
Cancer Res. 49:219-225(1989)

PubMed=2019470; DOI=10.1002/ijc.2910480221
Tohru Sugimoto, Hisao Ueyama, Hajime Hosoi, Johji Inazawa, Taiji Kato, John T. Kemshead, Charles Patrick Reynolds, Allen M. Gown, Hiroshi Mine, Tadashi Sawada;
Alpha-smooth-muscle actin and desmin expressions in human neuroblastoma cell lines.
Int. J. Cancer 48:277-283(1991)

DOI=10.1016/B978-0-12-333530-2.50006-X
Mark A. Israel, Carol Jeanne Thiele;
Tumor cell lines of the peripheral nervous system.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.43-78; Academic Press; New York; USA (1994)

DOI=10.1007/0-306-46872-7_2
Carol Jeanne Thiele;
Neuroblastoma.
(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999)

PubMed=12702577
Fumiko Saito-Ohara, Issei Imoto, Jun Inoue, Hajime Hosoi, Akira Nakagawara, Tohru Sugimoto, Johji Inazawa;
PPM1D is a potential target for 17q gain in neuroblastoma.
Cancer Res. 63:1876-1883(2003)

PubMed=15150091; DOI=10.1158/0008-5472.CAN-03-0809
Karl-Ludwig Schaefer, Kristin Brachwitz, Daniel H. Wai, Yvonne Braun, Raihanatou Diallo, Eberhard Korsching, Martin Eisenacher, Reinhard Voss, Frans van Valen, Claudia Baer, Barbara Selle ...Show all 18 authors... , Laura Spahn, Shuen-Kuei Liao, Kevin A.W. Lee, Pancras Cornelis Wilhelmus Hogendoorn, Guido Reifenberger, Helmut Erich Gabbert, Christopher Poremba; Show fewer authors
Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3.
Cancer Res. 64:3395-3405(2004)

PubMed=15720811; DOI=10.1593/neo.04310; PMCID=PMC1531688
Jeanette D. Walton, David R. Kattan, Sharon K. Thomas, Barbara A. Spengler, Hong-Fen Guo, June Lee Biedler, Nai-Kong V. Cheung, Robert A. Ross;
Characteristics of stem cells from human neuroblastoma cell lines and in tumors.
Neoplasia 6:838-845(2004)

PubMed=15892104; DOI=10.1002/gcc.20198
Yael P. Mosse, Joel Greshock, Adam A. Margolin, Tara Naylor, Kristina A. Cole, Deepa Khazi, George Hii, Cynthia Winter, Syed Shahzad, Muhammad Usman Asziz, Jaclyn A. Biegel ...Show all 13 authors... , Barbara L. Weber, John Matthew Maris; Show fewer authors
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Genes Chromosomes Cancer 43:390-403(2005)

PubMed=16822308; DOI=10.1186/1471-2407-6-177; PMCID=PMC1533846
Vincent Dam, Brian T. Morgan, Pavel Mazanek, Michael D. Hogarty;
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177.1-177.10(2006)

PubMed=18724359; DOI=10.1038/nature07261; PMCID=PMC2672043
Yael P. Mosse, Marci Laudenslager, Luca Longo, Kristina A. Cole, Andrew Wood, Edward Fathi Attiyeh, Michael J. Laquaglia, Rachel Sennett, Jill E. Lynch, Patrizia Perri, Genevieve Laureys ...Show all 22 authors... , Frank Speleman, Cecilia Kim, Cui-Ping Hou, Hakon Hakonarson, Ali Torkamani, Nicholas J. Schork, Garrett M. Brodeur, Gian Paolo Tonini, Eric Rappaport, Marcella Devoto, John Matthew Maris; Show fewer authors
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=23202128; DOI=10.1038/ng.2493; PMCID=PMC3557959
Mark Sausen, Rebecca J. Leary, Sian Jones, Jian Wu, Charles Patrick Reynolds, Xue-Yuan Liu, Amanda L. Blackford, Giovanni Parmigiani, Luis Alberto Diaz Jr., Nickolas Papadopoulos, Bert Vogelstein ...Show all 14 authors... , Kenneth Wayne Kinzler, Victor E. Velculescu, Michael D. Hogarty; Show fewer authors
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=24792489; DOI=10.1007/s11060-014-1456-8
Ahsan S. Farooqi, Rebecca A. Dagg, L. Mi Rim Choi, Jerry W. Shay, Charles Patrick Reynolds, Loretta M.S. Lau;
Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations.
J. Neurooncol. 119:17-26(2014)

PubMed=25884760; DOI=10.1371/journal.pcbi.1004130; PMCID=PMC4401789
Juan Palacios-Moreno, Lauren Foltz, Ai-Lan Guo, Matthew P. Stokes, Emily D. Kuehn, Lynn George, Michael J. Comb, Mark L. Grimes;
Neuroblastoma tyrosine kinase signaling networks involve FYN and LYN in endosomes and lipid rafts.
PLoS Comput. Biol. 11:e1004130.1-e1004130.33(2015)

PubMed=26342562; DOI=10.1016/j.scr.2015.08.008; PMCID=PMC4601571
Robert A. Ross, Jeanette D. Walton, Dan Han, Hong-Fen Guo, Nai-Kong V. Cheung;
A distinct gene expression signature characterizes human neuroblastoma cancer stem cells.
Stem Cell Res. 15:419-426(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7133
CGH-DB; 71-1
CGH-DB; 9091-4
Anatomy/cell type resources BTO; BTO_0003548
Encyclopedic resources Wikidata; Q54954990
Experimental variables resources EFO; EFO_0022537
Gene expression databases GEO; GSM3145570
GEO; GSM3145730
Polymorphism and mutation databases Cosmic; 717426
Cosmic; 848940
Cosmic; 923827
Cosmic; 1019932
Cosmic; 1162007
Cosmic; 1890077
Cosmic; 2393632
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number30