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Cellosaurus SCC-61 (CVCL_7118)

[Text version]
Cell line name SCC-61
Synonyms SCC 61; SCC61
Accession CVCL_7118
Resource Identification Initiative To cite this cell line use: SCC-61 (RRID:CVCL_7118)
Comments Part of: MD Anderson Cell Lines Project.
Characteristics: Good model for studying radiation resistance in squamous cell carcinoma (Millipore=SCC280).
Characteristics: Sensitive to radiation (PubMed=2004949).
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Oral cavity, tongue, anterior part; UBERON=UBERON_0010032.
Sequence variations
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_7086 (Nu61)CVCL_V282 (SCC-61B)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Millipore=SCC280; PubMed=21868764

Markers:
AmelogeninX,Y
CSF1PO10,12
D3S135815
D5S81812,13
D7S8208,12
D8S117912,14
D13S31710,12
D16S5399,11
D18S5112,14
D21S1128,30
FGA22,25
Penta D10,12
Penta E7,11
TH017,9
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Info; StRAP; -; https://strap.nci.nih.gov/celline_detail.php?sample_id=79
Publications

PubMed=6722007; DOI=10.1038/bjc.1984.94; PMCID=PMC1976725
Ralph R. Weichselbaum, William K. Dahlberg, John Bertram Little, Thomas J. Ervin, Daniel Miller, Samuel Hellman, James George Rheinwald;
Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy.
Br. J. Cancer 49:595-601(1984)

PubMed=3458227; DOI=10.1073/pnas.83.8.2684; PMCID=PMC323364
Ralph R. Weichselbaum, William K. Dahlberg, Michael A. Beckett, Theodore Karrison, Daniel Miller, John Clark, Thomas J. Ervin;
Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients.
Proc. Natl. Acad. Sci. U.S.A. 83:2684-2688(1986)

PubMed=3182330; DOI=10.1016/0360-3016(88)90125-3
Jeffrey L. Schwartz, Jacob Rotmensch, Susan Giovanazzi, Marvin B. Cohen, Ralph R. Weichselbaum;
Faster repair of DNA double-strand breaks in radioresistant human tumor cells.
Int. J. Radiat. Oncol. Biol. Phys. 15:907-912(1988)

PubMed=2573646; DOI=10.1080/09553008914551731
Ralph R. Weichselbaum, Jacob Rotmensch, Sijsan Ahmed-Swan, Michael A. Beckett;
Radiobiological characterization of 53 human tumor cell lines.
Int. J. Radiat. Biol. 56:553-560(1989)

PubMed=2380097; DOI=10.1016/0360-3016(90)90136-8
Dennis E. Hallahan, Michael A. Beckett, Donald William Kufe, Ralph R. Weichselbaum;
The interaction between recombinant human tumor necrosis factor and radiation in 13 human tumor cell lines.
Int. J. Radiat. Oncol. Biol. Phys. 19:69-74(1990)

PubMed=2394610; DOI=10.1016/0360-3016(90)90539-V
Ralph R. Weichselbaum, Michael A. Beckett, Srinivasan Vijayakumar, Michael A. Simon, Azhar M. Awan, James Nachman, William R. Panje, Michael E. Goldman, Allen G. Tybor, William J. Moran, Everett E. Vokes ...Show all 13 authors... , Sijsan Ahmed-Swan, Edward Farhangi; Show fewer authors
Radiobiological characterization of head and neck and sarcoma cells derived from patients prior to radiotherapy.
Int. J. Radiat. Oncol. Biol. Phys. 19:313-319(1990)

PubMed=2004949; DOI=10.1016/0360-3016(91)90016-W
Coral Ann Quiet, Ralph R. Weichselbaum, David J. Grdina;
Variation in radiation sensitivity during the cell cycle of two human squamous cell carcinomas.
Int. J. Radiat. Oncol. Biol. Phys. 20:733-738(1991)

PubMed=1574572; DOI=10.2307/3578273
Edward J. Dunphy, Michael A. Beckett, Lawrence H. Thompson, Ralph R. Weichselbaum;
Expression of the polymorphic human DNA repair gene XRCC1 does not correlate with radiosensitivity in the cells of human head and neck tumor cell lines.
Radiat. Res. 130:166-170(1992)

PubMed=8339273
David G. Brachman, Michael A. Beckett, Deborah Graves, Daniel Haraf, Everett E. Vokes, Ralph R. Weichselbaum;
p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines.
Cancer Res. 53:3667-3669(1993)

DOI=10.1016/B978-0-12-333530-2.50007-1
Thomas E. Carey;
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=7938462; DOI=10.2307/3578897
Monique F.M.A. Smeets, Els H.M. Dahmen-Mooren, Abdel Hady Ali Abdel-Wahab, Harry Bartelink, Adrian C. Begg;
Differential repair of radiation-induced DNA damage in cells of human squamous cell carcinoma and the effect of caffeine and cysteamine on induction and repair of DNA double-strand breaks.
Radiat. Res. 140:153-160(1994)

DOI=10.1007/978-1-4615-2023-8_7
Ralph R. Weichselbaum, Michael A. Beckett, Everett E. Vokes, David G. Brachman, Daniel Haraf, Dennis E. Hallahan, Donald William Kufe;
Cellular and molecular mechanisms of radioresistance.
(In book chapter) Head and neck cancer. Cancer treatment and research, Vol. 74; Hong, Waun Ki & Weber, Randal S. (eds.); pp.131-140; Springer; Boston; USA (1995)

PubMed=17312569; DOI=10.1002/hed.20478
Charles J. Lin, Jennifer Rubin Grandis, Thomas E. Carey, Susanne M. Gollin, Theresa L. Whiteside, Wayne M. Koch, Robert Louis Ferris, Stephen Y. Lai;
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=17848307; DOI=10.1016/j.ijrobp.2007.04.082
Wendell Gray Yarbrough, Amy Whigham, Brandee Brown, Michael Roach, Robbert J.C. Slebos;
Phosphoinositide kinase-3 status associated with presence or absence of human papillomavirus in head and neck squamous cell carcinomas.
Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Nene N. Kalu, Tuhina Mazumdar, Shao-Hua Peng, Li Shen, Vaishnav Sambandam, Xia-Yu Rao, Yuan-Xin Xi, Le-Rong Li, Yuan Qi, Frederico O. Gleber-Netto, Ameeta Patel ...Show all 16 authors... , Jing Wang, Mitchell J. Frederick, Jeffrey N. Myers, Curtis R. Pickering, Faye M. Johnson; Show fewer authors
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

Cross-references
Cell line collections (Providers) Millipore; SCC280
Encyclopedic resources Wikidata; Q54952349
Polymorphism and mutation databases Cosmic; 1122673
Cosmic; 1530756
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number26