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Cellosaurus BL-60 (CVCL_7034)

[Text version]
Cell line name BL-60
Synonyms BL60; BL 60; BL 060; IARC/BL60; IARC/BL 60; IARC-BL60; IARC BL60; IARC BL 60
Accession CVCL_7034
Resource Identification Initiative To cite this cell line use: BL-60 (RRID:CVCL_7034)
Comments From: International Agency of Research on Cancer (IARC); Lyon; France.
Population: Algerian.
Virology: Contains an integrated EBV genome (PubMed=8382295).
Doubling time: ~48 hours (DSMZ=ACC-953).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Bone, jaw; UBERON=UBERON_0001708.
Sequence variations
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_IV17 ! IARC-261
CVCL_IV06 ! IARC-277
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
Publications

PubMed=6087353; DOI=10.1073/pnas.81.15.4930
Bornkamm G.-W., von Knebel-Doeberitz M., Lenoir G.M.
No evidence for differences in the Epstein-Barr virus genome carried in Burkitt lymphoma cells and nonmalignant lymphoblastoid cells from the same patients.
Proc. Natl. Acad. Sci. U.S.A. 81:4930-4934(1984)

PubMed=2985508; DOI=10.1002/ijc.2910350404
Rowe M., Rooney C.M., Rickinson A.B., Lenoir G.M., Rupani H., Moss D.J., Stein H., Epstein M.A.
Distinctions between endemic and sporadic forms of Epstein-Barr virus-positive Burkitt's lymphoma.
Int. J. Cancer 35:435-441(1985)

PubMed=3934070
Lenoir G.M., Vuillaume M., Bonnardel C.
The use of lymphomatous and lymphoblastoid cell lines in the study of Burkitt's lymphoma.
IARC Sci. Publ. 60:309-318(1985)

PubMed=3026973; DOI=10.1002/ijc.2910390215
Ehlin-Henriksson B., Manneborg-Sandlund A., Klein G.
Expression of B-cell-specific markers in different Burkitt lymphoma subgroups.
Int. J. Cancer 39:211-218(1987)

PubMed=3027441; DOI=10.1093/jnci/78.2.235
Cohen J.H.M., Revillard J.-P., Magaud J.-P., Lenoir G.M., Vuillaume M., Manel A.-M., Vincent C., Bryon P.-A.
B-cell maturation stages of Burkitt's lymphoma cell lines according to Epstein-Barr virus status and type of chromosome translocation.
J. Natl. Cancer Inst. 78:235-242(1987)

PubMed=3035497; DOI=10.1093/nar/15.11.4553
Szajnert M.-F., Saule S., Bornkamm G.-W., Wajcman H., Lenoir G.M., Kaplan J.-C.
Clustered somatic mutations in and around first exon of non-rearranged c-myc in Burkitt lymphoma with t(8;22) translocation.
Nucleic Acids Res. 15:4553-4565(1987)

PubMed=2898508; DOI=10.1084/jem.167.6.1811
Gregory C.D., Murray R.J., Edwards C.F., Rickinson A.B.
Downregulation of cell adhesion molecules LFA-3 and ICAM-1 in Epstein-Barr virus-positive Burkitt's lymphoma underlies tumor cell escape from virus-specific T cell surveillance.
J. Exp. Med. 167:1811-1824(1988)

PubMed=1945409
Polack A., Strobl L., Feederle R., Schweizer M., Koch E., Eick D., Wiegand H., Bornkamm G.-W.
The intron enhancer of the immunoglobulin kappa gene activates c-myc but does not induce the Burkitt-specific promoter shift.
Oncogene 6:2033-2040(1991)

PubMed=2052620; DOI=10.1073/pnas.88.12.5413
Gaidano G., Ballerini P., Gong J.Z., Inghirami G., Neri A., Newcomb E.W., Magrath I.T., Knowles D.M., Dalla-Favera R.
p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.
Proc. Natl. Acad. Sci. U.S.A. 88:5413-5417(1991)

PubMed=1356511; DOI=10.1182/blood.V80.7.1781.1781
Gaidano G., Hauptschein R.S., Parsa N.Z., Offit K., Rao P.H., Lenoir G.M., Knowles D.M., Chaganti R.S.K., Dalla-Favera R.
Deletions involving two distinct regions of 6q in B-cell non-Hodgkin lymphoma.
Blood 80:1781-1787(1992)

PubMed=8382295; DOI=10.1128/JVI.67.3.1292-1299.1993
Delecluse H.-J., Bartnitzke S., Hammerschmidt W., Bullerdiek J., Bornkamm G.-W.
Episomal and integrated copies of Epstein-Barr virus coexist in Burkitt lymphoma cell lines.
J. Virol. 67:1292-1299(1993)

PubMed=7519050; DOI=10.1002/gcc.2870090408
Zeidler R., Joos S., Delecluse H.-J., Klobeck G., Vuillaume M., Lenoir G.M., Bornkamm G.-W., Lipp M.
Breakpoints of Burkitt's lymphoma t(8;22) translocations map within a distance of 300 kb downstream of MYC.
Genes Chromosomes Cancer 9:282-287(1994)

PubMed=9473234; DOI=10.1182/blood.V91.5.1680
Klangby U., Okan I., Magnusson K.P., Wendland M., Lind P., Wiman K.G.
p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma.
Blood 91:1680-1687(1998)

PubMed=10997876; DOI=10.1093/dnares/7.4.261
Hauptschein R.S., Gaidano G., Rao P.H., Scotto L., Edwards Y.H., Chaganti R.S.K., Dalla-Favera R.
An apparent interlocus gene conversion-like event at a putative tumor suppressor gene locus on human chromosome 6q27 in a Burkitt's lymphoma cell line.
DNA Res. 7:261-272(2000)

PubMed=11793449; DOI=10.1002/gcc.10022
Sobol H., Benziane A., Kerangueven F., Yin L., Noguchi T., Pauly S., Eisinger F., Longy M., Romeo G., Lenoir G.M., Birnbaum D.
Genome-wide search for loss of heterozygosity in Burkitt lymphoma cell lines.
Genes Chromosomes Cancer 33:217-224(2002)

PubMed=19358282; DOI=10.1002/ijc.24351
Inagaki A., Ishida T., Yano H., Ishii T., Kusumoto S., Ito A., Ri M., Mori F., Ding J.-M., Komatsu H., Iida S., Ueda R.
Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.
Int. J. Cancer 125:212-221(2009)

PubMed=24590883; DOI=10.1002/gcc.22161
Murga Penas E.-M., Schilling G., Behrmann P., Klokow M., Vettorazzi E., Bokemeyer C., Dierlamm J.
Comprehensive cytogenetic and molecular cytogenetic analysis of 44 Burkitt lymphoma cell lines: secondary chromosomal changes characterization, karyotypic evolution, and comparison with primary samples.
Genes Chromosomes Cancer 53:497-515(2014)

Cross-references
Cell line collections (Providers) DSMZ; ACC-953
Cell line databases/resources cancercelllines; CVCL_7034
Anatomy/cell type resources BTO; BTO:0001934
Encyclopedic resources Wikidata; Q54797225
Polymorphism and mutation databases Cosmic; 931100
IARC_TP53; 137
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number23