ID   BL-60
AC   CVCL_7034
SY   BL60; BL 60; BL 060; IARC/BL60; IARC/BL 60; IARC-BL60; IARC BL60; IARC BL 60
DR   BTO; BTO:0001934
DR   cancercelllines; CVCL_7034
DR   Cosmic; 931100
DR   DSMZ; ACC-953
DR   IARC_TP53; 137
DR   Wikidata; Q54797225
RX   PubMed=1356511;
RX   PubMed=1945409;
RX   PubMed=2052620;
RX   PubMed=2898508;
RX   PubMed=2985508;
RX   PubMed=3026973;
RX   PubMed=3027441;
RX   PubMed=3035497;
RX   PubMed=3934070;
RX   PubMed=6087353;
RX   PubMed=7519050;
RX   PubMed=8382295;
RX   PubMed=9473234;
RX   PubMed=10997876;
RX   PubMed=11793449;
RX   PubMed=19358282;
RX   PubMed=24590883;
CC   From: International Agency of Research on Cancer (IARC); Lyon; France.
CC   Population: Algerian.
CC   Virology: Contains an integrated EBV genome (PubMed=8382295).
CC   Doubling time: ~48 hours (DSMZ=ACC-953).
CC   Sequence variation: Gene fusion; HGNC; 5853; IGL + HGNC; 7553; MYC; Name(s)=MYC-IGL (PubMed=1945409; PubMed=7519050).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg282Trp (c.844C>T); ClinVar=VCV000012364; Zygosity=Unspecified (PubMed=2052620).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Derived from site: In situ; Bone, jaw; UBERON=UBERON_0001708.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_IV17 ! IARC-261
OI   CVCL_IV06 ! IARC-277
SX   Female
AG   4Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 24
//
RX   PubMed=1356511; DOI=10.1182/blood.V80.7.1781.1781;
RA   Gaidano G., Hauptschein R.S., Parsa N.Z., Offit K., Rao P.H.,
RA   Lenoir G.M., Knowles D.M., Chaganti R.S.K., Dalla-Favera R.;
RT   "Deletions involving two distinct regions of 6q in B-cell non-Hodgkin
RT   lymphoma.";
RL   Blood 80:1781-1787(1992).
//
RX   PubMed=1945409;
RA   Polack A., Strobl L., Feederle R., Schweizer M., Koch E., Eick D.,
RA   Wiegand H., Bornkamm G.-W.;
RT   "The intron enhancer of the immunoglobulin kappa gene activates c-myc
RT   but does not induce the Burkitt-specific promoter shift.";
RL   Oncogene 6:2033-2040(1991).
//
RX   PubMed=2052620; DOI=10.1073/pnas.88.12.5413;
RA   Gaidano G., Ballerini P., Gong J.Z., Inghirami G., Neri A.,
RA   Newcomb E.W., Magrath I.T., Knowles D.M., Dalla-Favera R.;
RT   "p53 mutations in human lymphoid malignancies: association with
RT   Burkitt lymphoma and chronic lymphocytic leukemia.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:5413-5417(1991).
//
RX   PubMed=2898508; DOI=10.1084/jem.167.6.1811;
RA   Gregory C.D., Murray R.J., Edwards C.F., Rickinson A.B.;
RT   "Downregulation of cell adhesion molecules LFA-3 and ICAM-1 in
RT   Epstein-Barr virus-positive Burkitt's lymphoma underlies tumor cell
RT   escape from virus-specific T cell surveillance.";
RL   J. Exp. Med. 167:1811-1824(1988).
//
RX   PubMed=2985508; DOI=10.1002/ijc.2910350404;
RA   Rowe M., Rooney C.M., Rickinson A.B., Lenoir G.M., Rupani H.,
RA   Moss D.J., Stein H., Epstein M.A.;
RT   "Distinctions between endemic and sporadic forms of Epstein-Barr
RT   virus-positive Burkitt's lymphoma.";
RL   Int. J. Cancer 35:435-441(1985).
//
RX   PubMed=3026973; DOI=10.1002/ijc.2910390215;
RA   Ehlin-Henriksson B., Manneborg-Sandlund A., Klein G.;
RT   "Expression of B-cell-specific markers in different Burkitt lymphoma
RT   subgroups.";
RL   Int. J. Cancer 39:211-218(1987).
//
RX   PubMed=3027441; DOI=10.1093/jnci/78.2.235;
RA   Cohen J.H.M., Revillard J.-P., Magaud J.-P., Lenoir G.M., Vuillaume M.,
RA   Manel A.-M., Vincent C., Bryon P.-A.;
RT   "B-cell maturation stages of Burkitt's lymphoma cell lines according
RT   to Epstein-Barr virus status and type of chromosome translocation.";
RL   J. Natl. Cancer Inst. 78:235-242(1987).
//
RX   PubMed=3035497; DOI=10.1093/nar/15.11.4553;
RA   Szajnert M.-F., Saule S., Bornkamm G.-W., Wajcman H., Lenoir G.M.,
RA   Kaplan J.-C.;
RT   "Clustered somatic mutations in and around first exon of
RT   non-rearranged c-myc in Burkitt lymphoma with t(8;22) translocation.";
RL   Nucleic Acids Res. 15:4553-4565(1987).
//
RX   PubMed=3934070;
RA   Lenoir G.M., Vuillaume M., Bonnardel C.;
RT   "The use of lymphomatous and lymphoblastoid cell lines in the study of
RT   Burkitt's lymphoma.";
RL   IARC Sci. Publ. 60:309-318(1985).
//
RX   PubMed=6087353; DOI=10.1073/pnas.81.15.4930;
RA   Bornkamm G.-W., von Knebel-Doeberitz M., Lenoir G.M.;
RT   "No evidence for differences in the Epstein-Barr virus genome carried
RT   in Burkitt lymphoma cells and nonmalignant lymphoblastoid cells from
RT   the same patients.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:4930-4934(1984).
//
RX   PubMed=7519050; DOI=10.1002/gcc.2870090408;
RA   Zeidler R., Joos S., Delecluse H.-J., Klobeck H.-G., Vuillaume M.,
RA   Lenoir G.M., Bornkamm G.-W., Lipp M.;
RT   "Breakpoints of Burkitt's lymphoma t(8;22) translocations map within a
RT   distance of 300 kb downstream of MYC.";
RL   Genes Chromosomes Cancer 9:282-287(1994).
//
RX   PubMed=8382295; DOI=10.1128/JVI.67.3.1292-1299.1993;
RA   Delecluse H.-J., Bartnitzke S., Hammerschmidt W., Bullerdiek J.,
RA   Bornkamm G.-W.;
RT   "Episomal and integrated copies of Epstein-Barr virus coexist in
RT   Burkitt lymphoma cell lines.";
RL   J. Virol. 67:1292-1299(1993).
//
RX   PubMed=9473234; DOI=10.1182/blood.V91.5.1680;
RA   Klangby U., Okan I., Magnusson K.P., Wendland M., Lind P., Wiman K.G.;
RT   "p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a
RT   mRNA and protein expression in Burkitt's lymphoma.";
RL   Blood 91:1680-1687(1998).
//
RX   PubMed=10997876; DOI=10.1093/dnares/7.4.261;
RA   Hauptschein R.S., Gaidano G., Rao P.H., Scotto L., Edwards Y.H.,
RA   Chaganti R.S.K., Dalla-Favera R.;
RT   "An apparent interlocus gene conversion-like event at a putative tumor
RT   suppressor gene locus on human chromosome 6q27 in a Burkitt's
RT   lymphoma cell line.";
RL   DNA Res. 7:261-272(2000).
//
RX   PubMed=11793449; DOI=10.1002/gcc.10022;
RA   Sobol H., Benziane A., Kerangueven F., Yin L., Noguchi T., Pauly S.,
RA   Eisinger F., Longy M., Romeo G., Lenoir G.M., Birnbaum D.;
RT   "Genome-wide search for loss of heterozygosity in Burkitt lymphoma
RT   cell lines.";
RL   Genes Chromosomes Cancer 33:217-224(2002).
//
RX   PubMed=19358282; DOI=10.1002/ijc.24351;
RA   Inagaki A., Ishida T., Yano H., Ishii T., Kusumoto S., Ito A., Ri M.,
RA   Mori F., Ding J.-M., Komatsu H., Iida S., Ueda R.;
RT   "Expression of the ULBP ligands for NKG2D by B-NHL cells plays an
RT   important role in determining their susceptibility to
RT   rituximab-induced ADCC.";
RL   Int. J. Cancer 125:212-221(2009).
//
RX   PubMed=24590883; DOI=10.1002/gcc.22161;
RA   Murga Penas E.-M., Schilling G., Behrmann P., Klokow M.,
RA   Vettorazzi E., Bokemeyer C., Dierlamm J.;
RT   "Comprehensive cytogenetic and molecular cytogenetic analysis of 44
RT   Burkitt lymphoma cell lines: secondary chromosomal changes
RT   characterization, karyotypic evolution, and comparison with primary
RT   samples.";
RL   Genes Chromosomes Cancer 53:497-515(2014).
//