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Cellosaurus HPLA-A3 (CVCL_6G77)

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Cell line name HPLA-A3
Accession CVCL_6G77
Resource Identification Initiative To cite this cell line use: HPLA-A3 (RRID:CVCL_6G77)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:7968; NR1I2.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=22687401; DOI=10.1248/bpb.35.677
Masashi Sekimoto, Shinsuke Sano, Takuomi Hosaka, Kiyomitsu Nemoto, Masakuni Degawa;
Establishment of a stable human cell line, HPL-A3, for use in reporter gene assays of cytochrome P450 3A inducers.
Biol. Pharm. Bull. 35:677-685(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6G77
Encyclopedic resources Wikidata; Q54890298
Entry history
Entry creation23-Feb-2016
Last entry update14-Aug-2025
Version number17