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Cellosaurus HIOEC (CVCL_6E43)

[Text version]
Cell line name HIOEC
Synonyms Human Immortalized Oral Epithelial Cells
Accession CVCL_6E43
Resource Identification Initiative To cite this cell line use: HIOEC (RRID:CVCL_6E43)
Comments Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Oral cavity, oral mucosa; UBERON=UBERON_0003729.
Cell type: Epithelial cell; CL=CL_0000066.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C1LE (HIOEC-B(a)P-56)CVCL_6E44 (HIOEC-B(a)P-96)CVCL_C1LG (HIOEC-B(a)P-TPA)
Sex of cell Female
Age at sampling Age unspecified
Category Transformed cell line
Publications

Patent=CN1730663A
Zhi-Yuan Zhang, Hong-Ya Pan, Jun Cao, Ti-Man Pa, Xiao-Jian Zhou, Wan-Tao Chen, Jiang Li, Ping Zhang, Rong-Gen He;
A kind of oral mucosa epithelial cell canceration model.
Patent number CN1730663A, 08-Feb-2006

PubMed=16513324; DOI=10.1016/j.ijom.2006.01.017
Patima Sdek, Zhi-Yuan Zhang, Jun Cao, H.-Y. Pan, Wan-Tao Chen, Jia-Wei Zheng;
Alteration of cell-cycle regulatory proteins in human oral epithelial cells immortalized by HPV16 E6 and E7.
Int. J. Oral Maxillofac. Surg. 35:653-657(2006)

PubMed=16685356
Hong-Ya Pan, Zhi-Yuan Zhang, Xiao-Jian Zhou, Jiang Li, Ping Zhang, Wan-Tao Chen;
The establishment of B(a)P and TPA transformed cell line and its biological characteristics.
Shanghai Kou Qiang Yi Xue 15:152-156(2006)

PubMed=18206853; DOI=10.1016/j.archoralbio.2007.12.002
Lai-Ping Zhong, Hong-Ya Pan, Xiao-Jian Zhou, Dong-Xia Ye, Lei Zhang, Xiao Yang, Wan-Tao Chen, Zhi-Yuan Zhang;
Characteristics of a cancerous cell line, HIOEC-B(a)P-96, induced by benzo(a)pyrene from human immortalized oral epithelial cell line.
Arch. Oral Biol. 53:443-452(2008)

Cross-references
Encyclopedic resources Wikidata; Q54889587
Entry history
Entry creation23-Feb-2016
Last entry update14-Aug-2025
Version number13