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Cellosaurus MCF-7/TMX2-28 (CVCL_6957)

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Cell line name MCF-7/TMX2-28
Synonyms TMX2-28
Accession CVCL_6957
Resource Identification Initiative To cite this cell line use: MCF-7/TMX2-28 (RRID:CVCL_6957)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_41774; Tamoxifen.
Omics: Genomics; DNA methylation analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4Y63 (MCF-7/TMX2)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=12943988; DOI=10.1016/S0303-7207(03)00256-9
Michael J. Fasco, Agita Amin, Brian T. Pentecost, Yi Yang, John F. Gierthy;
Phenotypic changes in MCF-7 cells during prolonged exposure to tamoxifen.
Mol. Cell. Endocrinol. 206:33-47(2003)

PubMed=17189381; DOI=10.1158/1541-7786.MCR-06-0147
Joseph M. Gozgit, Brian T. Pentecost, Sharon A. Marconi, Christopher N. Otis, Chuan-Yue Wu, Kathleen F. Arcaro;
Use of an aggressive MCF-7 cell line variant, TMX2-28, to study cell invasion in breast cancer.
Mol. Cancer Res. 4:905-913(2006)

PubMed=24225485; DOI=10.4161/epi.27111; PMCID=PMC3962540
Kristin E. Williams, Douglas L. Anderton, Maxwell P. Lee, Brian T. Pentecost, Kathleen F. Arcaro;
High-density array analysis of DNA methylation in Tamoxifen-resistant breast cancer cell lines.
Epigenetics 9:297-307(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6957
Encyclopedic resources Wikidata; Q54904394
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number22