ID   MCF-7/TMX2-28
AC   CVCL_6957
SY   TMX2-28
DR   cancercelllines; CVCL_6957
DR   Wikidata; Q54904394
RX   PubMed=12943988;
RX   PubMed=17189381;
RX   PubMed=24225485;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_41774; Tamoxifen.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Omics: Genomics; DNA methylation analysis.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4Y63 ! MCF-7/TMX2
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 22
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RX   PubMed=12943988; DOI=10.1016/S0303-7207(03)00256-9;
RA   Fasco M.J., Amin A., Pentecost B.T., Yang Y., Gierthy J.F.;
RT   "Phenotypic changes in MCF-7 cells during prolonged exposure to
RT   tamoxifen.";
RL   Mol. Cell. Endocrinol. 206:33-47(2003).
//
RX   PubMed=17189381; DOI=10.1158/1541-7786.MCR-06-0147;
RA   Gozgit J.M., Pentecost B.T., Marconi S.A., Otis C.N., Wu C.-Y.,
RA   Arcaro K.F.;
RT   "Use of an aggressive MCF-7 cell line variant, TMX2-28, to study cell
RT   invasion in breast cancer.";
RL   Mol. Cancer Res. 4:905-913(2006).
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RX   PubMed=24225485; DOI=10.4161/epi.27111; PMCID=PMC3962540;
RA   Williams K.E., Anderton D.L., Lee M.P., Pentecost B.T., Arcaro K.F.;
RT   "High-density array analysis of DNA methylation in Tamoxifen-resistant
RT   breast cancer cell lines.";
RL   Epigenetics 9:297-307(2014).
//