Cell line name |
OCM-8 |
Synonyms |
OCM8; Ocm8; ocm-8 |
Accession |
CVCL_6938 |
Resource Identification Initiative |
To cite this cell line use: OCM-8 (RRID:CVCL_6938) |
Comments |
Problematic cell line: Contaminated. Shown to be a SK-MEL-28 derivative (PubMed=22236444 and STR profile from PubMed=18689700). Originally thought to originate from an uveal melanoma. From: Kan-Mitchell J.; Wayne State University; Detroit; USA. Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00504. |
Sequence variations |
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (PubMed=22236444).
- Mutation; HGNC; 1773; CDK4; Simple; p.Arg24Cys (c.70C>T); ClinVar=VCV000016928; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 3236; EGFR; Simple; p.Pro753Ser (c.2257C>T); ClinVar=VCV000376081; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Thr167Ala (c.499A>G); ClinVar=VCV001686107; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11730; TERT; Simple; c.-57A>C (c.161A>C) (A161C); ClinVar=VCV000242210; Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Leu145Arg (c.434T>G); ClinVar=VCV001027110; Zygosity=Homozygous (from parent cell line).
|
Disease |
Cutaneous melanoma (NCIt: C3510) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0526 (SK-MEL-28) |
Sex of cell |
Male |
Age at sampling |
51Y |
Category |
Cancer cell line |
STR profile |
Source(s): ESTDAB; PubMed=18689700
Markers:Amelogenin | X,Y |
CSF1PO | 10,12 |
D3S1358 | 16,18 |
D5S818 | 11,13 |
D7S820 | 10 |
D8S1179 | 13 |
D13S317 | 11,12 |
D16S539 | 9,12 |
D18S51 | 12,16 |
D21S11 | 28,29 |
FGA | 19 |
TH01 | 7 |
TPOX | 8,12 |
vWA | 16,19 |
Run an STR similarity search on this cell line |
Web pages |
https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx |
Publications | PubMed=16772116; DOI=10.1016/j.cancergencyto.2005.11.016 White J.S., Becker R.L., McLean I.W., Director-Myska A.E., Nath J. Molecular cytogenetic evaluation of 10 uveal melanoma cell lines. Cancer Genet. Cytogenet. 168:11-21(2006) PubMed=18689700; DOI=10.1167/iovs.08-2324 Folberg R., Kadkol S.S., Frenkel S., Valyi-Nagy K., Jager M.J., Pe'er J., Maniotis A.J. Authenticating cell lines in ophthalmic research laboratories. Invest. Ophthalmol. Vis. Sci. 49:4697-4701(2008) PubMed=19340423; DOI=10.1007/s00262-009-0701-z Mendez R., Aptsiauri N., Del Campo A., Maleno I., Cabrera T., Ruiz-Cabello F., Garrido F., Garcia-Lora A. HLA and melanoma: multiple alterations in HLA class I and II expression in human melanoma cell lines from ESTDAB cell bank. Cancer Immunol. Immunother. 58:1507-1515(2009) PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x Griewank K.G., Yu X., Khalili J., Sozen M.M., Stempke-Hale K., Bernatchez C., Wardell S., Bastian B.C., Woodman S.E. Genetic and molecular characterization of uveal melanoma cell lines. Pigment Cell Melanoma Res. 25:182-187(2012) |
Cross-references |
Cell line databases/resources |
ESTDAB; ESTDAB-130
|
Biological sample resources |
BioSample; SAMN06481120
|
Encyclopedic resources |
Wikidata; Q54931810
|
Polymorphism and mutation databases |
Cosmic; 1320370
Cosmic; 1628410
|
Entry history |
Entry creation | 04-Apr-2012 |
Last entry update | 21-Mar-2023 |
Version number | 29 |
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