ID   OCM-8
AC   CVCL_6938
SY   OCM8; Ocm8; ocm-8
DR   BioSample; SAMN06481120
DR   cancercelllines; CVCL_6938
DR   Cosmic; 1320370
DR   Cosmic; 1628410
DR   ESTDAB; ESTDAB-130
DR   Wikidata; Q54931810
RX   PubMed=16772116;
RX   PubMed=18689700;
RX   PubMed=19340423;
RX   PubMed=22236444;
RX   PubMed=23849826;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a SK-MEL-28 derivative (PubMed=22236444 and STR profile from PubMed=18689700). Originally thought to originate from an uveal melanoma.
CC   From: Kan-Mitchell, June; Wayne State University; Detroit; USA.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00504.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (PubMed=22236444).
CC   Sequence variation: Mutation; HGNC; HGNC:1773; CDK4; Simple; p.Arg24Cys (c.70C>T); ClinVar=VCV000016928; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Pro753Ser (c.2257C>T); ClinVar=VCV000376081; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Thr167Ala (c.499A>G); ClinVar=VCV001686107; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.-57A>C (c.161A>C) (A161C); ClinVar=VCV000242210; Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu145Arg (c.434T>G); ClinVar=VCV001027110; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
CC   Cell type: Melanocyte of skin; CL=CL_1000458.
ST   Source(s): ESTDAB=ESTDAB-130; PubMed=18689700
ST   Amelogenin: X,Y
ST   CSF1PO: 10,12
ST   D13S317: 11,12
ST   D16S539: 9,12
ST   D18S51: 12,16
ST   D21S11: 28,29
ST   D3S1358: 16,18
ST   D5S818: 11,13
ST   D7S820: 10
ST   D8S1179: 13
ST   FGA: 19
ST   TH01: 7
ST   TPOX: 8,12
ST   vWA: 16,19
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0526 ! SK-MEL-28
SX   Male
AG   51Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 35
//
RX   PubMed=16772116; DOI=10.1016/j.cancergencyto.2005.11.016;
RA   White, Jason S.
RA   Becker, Robert L.
RA   McLean, Ian W.
RA   Director-Myska, Alison E.
RA   Nath, Joginder
RT   "Molecular cytogenetic evaluation of 10 uveal melanoma cell lines.";
RL   Cancer Genet. Cytogenet. 168:11-21(2006).
//
RX   PubMed=19340423; DOI=10.1007/s00262-009-0701-z; PMCID=PMC11030131;
RA   Mendez, Rosa
RA   Aptsiauri, Natalia
RA   Del Campo, Ana
RA   Maleno, Isabel
RA   Cabrera, Teresa
RA   Ruiz-Cabello Osuna, Francisco
RA   Garrido, Federico
RA   Garcia-Lora, Angel
RT   "HLA and melanoma: multiple alterations in HLA class I and II
RT   expression in human melanoma cell lines from ESTDAB cell bank.";
RL   Cancer Immunol. Immunother. 58:1507-1515(2009).
//
RX   PubMed=18689700; DOI=10.1167/iovs.08-2324; PMCID=PMC2576485;
RA   Folberg, Robert
RA   Kadkol, ShriHari S.
RA   Frenkel, Shahar
RA   Valyi-Nagy, Klara
RA   Jager, Martine Johanna
RA   Pe'er, Jacob
RA   Maniotis, Andrew J.
RT   "Authenticating cell lines in ophthalmic research laboratories.";
RL   Invest. Ophthalmol. Vis. Sci. 49:4697-4701(2008).
//
RX   PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x; PMCID=PMC3288394;
RA   Griewank, Klaus Georg
RA   Yu, Xiao-Xing
RA   Khalili, Jahan S.
RA   Sozen, Mustafa Mert
RA   Stemke-Hale, Katherine
RA   Bernatchez, Chantale
RA   Wardell, Seth
RA   Bastian, Boris C.
RA   Woodman, Scott E.
RT   "Genetic and molecular characterization of uveal melanoma cell
RT   lines.";
RL   Pigment Cell Melanoma Res. 25:182-187(2012).
//
RX   PubMed=23849826; DOI=10.1016/j.ejca.2013.06.011;
RA   Amaro, Adriana
RA   Mirisola, Valentina
RA   Angelini, Giovanna
RA   Musso, Alessandra
RA   Tosetti, Francesca Isabella
RA   Esposito, Alessia Isabella
RA   Perri, Patrizia
RA   Lanza, Francesco Baldo
RA   Nasciuti, Francesca
RA   Mosci, Carlo
RA   Puzone, Roberto
RA   Salvi, Sandra
RA   Truini, Mauro
RA   Poggi, Alessandro
RA   Pfeffer, Ulrich
RT   "Evidence of epidermal growth factor receptor expression in uveal
RT   melanoma: inhibition of epidermal growth factor-mediated signalling
RT   by gefitinib and cetuximab triggered antibody-dependent cellular
RT   cytotoxicity.";
RL   Eur. J. Cancer 49:3353-3365(2013).
//