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Cellosaurus ACCS (CVCL_6876)

[Text version]
Cell line name ACCS
Synonyms ACC-S
Accession CVCL_6876
Resource Identification Initiative To cite this cell line use: ACCS (RRID:CVCL_6876)
Comments Problematic cell line: Contaminated. Shown to be a T24 derivative (PubMed=19557180; PubMed=20143388). Originally thought to originate from a 56 year old female patient with a salivary gland adenoid cystic carcinoma.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00361.
Population: Caucasian; Swedish.
Omics: Genomics; Whole exome sequencing.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (DepMap=ACH-001011).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0554 (T24)
Sex of cell Female
Age at sampling 82Y
Category Cancer cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=2162254
Kanemitsu Shirasuna, Kazuya Watatani, Hideyuki Furusawa, Munehisa Saka, Shigeyuki Morioka, Hideo Yoshioka, Tokuzo Matsuya;
Biological characterization of pseudocyst-forming cell lines from human adenoid cystic carcinomas of minor salivary gland origin.
Cancer Res. 50:4139-4145(1990)

DOI=10.1007/0-306-46872-7_9
Mitsunobu Sato;
Salivary gland tumors.
(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.161-178; Kluwer Academic Publishers; New York; USA (1999)

PubMed=19557180; DOI=10.1371/journal.pone.0006040; PMCID=PMC2698276
Janyaporn Phuchareon, Yoshihito Ohta, Jonathan M. Woo, David William Eisele, Osamu Tetsu;
Genetic profiling reveals cross-contamination and misidentification of 6 adenoid cystic carcinoma cell lines: ACC2, ACC3, ACCM, ACCNS, ACCS and CAC2.
PLoS ONE 4:e6040.1-e6040.8(2009)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

DOI=10.4103/2468-5585.200513
Nan-Nan Liu, Sen-Lin Zhang, Wei Chen;
The cross-contaminated cell lines of adenoid cystic carcinoma: a crucial concern.
Transl. Surg. 2:10-13(2017)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6876
Cell_Model_Passport; SIDM01166
DepMap; ACH-001011 - Discontinued
Biological sample resources BioSample; SAMN03151936
BioSample; SAMN10989595
Chemistry resources PharmacoDB; ACCS_53_2019
Encyclopedic resources Wikidata; Q54608335
Polymorphism and mutation databases IARC_TP53; 28390
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number31