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Cellosaurus Caov-2 (CVCL_6861)

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Cell line name Caov-2
Synonyms CaOV-2; CAOV-2; CAOV2
Accession CVCL_6861
Resource Identification Initiative To cite this cell line use: Caov-2 (RRID:CVCL_6861)
Comments Problematic cell line: Contaminated. On the basis of its STR profile it seems to be a Calu-6 derivative. Originally thought to originate from an ovarian carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00458.
Population: Caucasian.
Omics: Transcriptomics; Microarray.
Caution: Was thought to be an OVCAR-2 derivative because its STR profile was identical to that originally reported for that cell line (PubMed=22710073). But this was shown (September 2025) not to be the correct STR profile for OVCAR-2. Meanwhile it was also noticed that the Caov-2 STR profile is identical to that of Calu-6.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Cell type: Epithelial cell; CL=CL_0000066.
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0236 (Calu-6)
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line
STR profile Source(s): PubMed=22710073

Markers:
AmelogeninX
CSF1PO12
D2S133817,26
D3S135816
D5S81811
D7S82010
D8S117910,14
D13S31711
D16S53913
D18S5112,16
D19S43313
D21S1131
FGA22
TH019
TPOX8
vWA17

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677
Christopher T. Korch, Monique Ann Spillman, Twila A. Jackson, Britta M. Jacobsen, Susan K. Murphy, Bruce Arthur Lessey, Virgil Craig Jordan, Andrew Peter Bradford;
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

Cross-references
Cell line collections (Providers) ATCC; HTB-74 - Discontinued
Biological sample resources BioSample; SAMN03151863
Encyclopedic resources Wikidata; Q54808583
Gene expression databases GEO; GSM711701
GEO; GSM851912
Entry history
Entry creation04-Apr-2012
Last entry update27-Nov-2025
Version number23