ID   Caov-2
AC   CVCL_6861
SY   CaOV-2; CAOV-2; CAOV2
DR   ATCC; HTB-74
DR   BioSample; SAMN03151863
DR   GEO; GSM711701
DR   GEO; GSM851912
DR   Wikidata; Q54808583
RX   PubMed=3518877;
RX   PubMed=22710073;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. On the basis of its STR profile it seems to be a Calu-6 derivative. Originally thought to originate from an ovarian carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00458.
CC   Population: Caucasian.
CC   Omics: Transcriptomics; Microarray.
CC   Caution: Was thought to be an OVCAR-2 derivative because its STR profile was identical to that originally reported for that cell line (PubMed=22710073). But this was shown (September 2025) not to be the correct STR profile for OVCAR-2. Meanwhile it was also noticed that the Caov-2 STR profile is identical to that of Calu-6.
CC   Discontinued: ATCC; HTB-74; true.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
CC   Cell type: Epithelial cell; CL=CL_0000066.
ST   Source(s): PubMed=22710073
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 11
ST   D16S539: 13
ST   D18S51: 12,16
ST   D19S433: 13
ST   D21S11: 31
ST   D2S1338: 17,26
ST   D3S1358: 16
ST   D5S818: 11
ST   D7S820: 10
ST   D8S1179: 10,14
ST   FGA: 22
ST   TH01: 9
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0236 ! Calu-6
SX   Female
AG   61Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 27-11-25; Version: 23
//
RX   PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677;
RA   Korch, Christopher T.
RA   Spillman, Monique Ann
RA   Jackson, Twila A.
RA   Jacobsen, Britta M.
RA   Murphy, Susan K.
RA   Lessey, Bruce Arthur
RA   Jordan, Virgil Craig
RA   Bradford, Andrew Peter
RT   "DNA profiling analysis of endometrial and ovarian cell lines reveals
RT   misidentification, redundancy and contamination.";
RL   Gynecol. Oncol. 127:241-248(2012).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh, Jorgen
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//