Cell line name |
P116 |
Accession |
CVCL_6429 |
Resource Identification Initiative |
To cite this cell line use: P116 (RRID:CVCL_6429) |
Comments |
Population: Caucasian. Omics: Phenotyping; Drug screening. Omics: Variations; SNP array analysis. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0367 (Jurkat E6.1) Children:
|
Sex of cell |
Male |
Age at sampling |
14Y |
Category |
Cancer cell line |
STR profile |
Source(s): ATCC=CRL-2676
Markers:Amelogenin | X |
CSF1PO | 11,12 |
D2S1338 | 18,23 |
D3S1358 | 15,17 |
D5S818 | 9 |
D7S820 | 8,11.3 |
D8S1179 | 13,14 |
D13S317 | 8,12 |
D16S539 | 11 |
D18S51 | 13,21 |
D19S433 | 14,15.2 |
D21S11 | 31.2,34.2 |
FGA | 20,21 |
Penta D | 11,13 |
Penta E | 10,12 |
TH01 | 6,9.3 |
TPOX | 8,10 |
vWA | 18,19 |
Run an STR similarity search on this cell line |
Publications | PubMed=9488454; DOI=10.1128/mcb.18.3.1388; PMCID=PMC108852 Brandi L. Williams, Kathy L. Schreiber, Wei-Guo Zhang, Ronald L. Wange, Lawrence E. Samelson, Paul J. Leibson, Robert T. Abraham; Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. Mol. Cell. Biol. 18:1388-1399(1998) PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662 S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res. 70:2158-2164(2010) |
Cross-references |
Cell line collections (Providers) |
ATCC; CRL-2676
|
Cell line databases/resources |
CLO; CLO_0008292
cancercelllines; CVCL_6429
TOKU-E; 2820
|
Biological sample resources |
BioSample; SAMN03471760
|
Chemistry resources |
GDSC; 1330986
PharmacoDB; P116_1229_2019
|
Encyclopedic resources |
Wikidata; Q54937222
|
Gene expression databases |
GEO; GSM827152
|
Polymorphism and mutation databases |
Progenetix; CVCL_6429
|
Entry history |
Entry creation | 04-Apr-2012 |
Last entry update | 10-Apr-2025 |
Version number | 29 |
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