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Cellosaurus B-3 (CVCL_6367)

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Cell line name B-3
Synonyms HLE-B3; HLE B-3; HLEB-3; HLEB3; HLEC-B3
Accession CVCL_6367
Secondary accession CVCL_8482
Resource Identification Initiative To cite this cell line use: B-3 (RRID:CVCL_6367)
Comments Group: Patented cell line.
Problematic cell line: Possibly misidentified. Presence of a Y chromosome in cell line that was thought to be of female origin (STR profile).
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11421.
Transformant: Ad12-SV40 hybrid virus.
Derived from site: In situ; Eye, ocular lens, epithelium; UBERON=UBERON_0001803.
Cell type: Epithelial cell of ocular lens; CL=CL_0002224.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 5-12M
Category Transformed cell line
STR profile Source(s): ATCC=CRL-3603

Markers:
AmelogeninX,Y
CSF1PO11
D5S8189,11
D7S82011
D13S31711
D16S53911,12
TH019.3
TPOX8
vWA14,19

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Publications

PubMed=8206728
Usha P. Andley, Johng Sik Rhim, Leo T. Chylack Jr., Timothy P. Fleming;
Propagation and immortalization of human lens epithelial cells in culture.
Invest. Ophthalmol. Vis. Sci. 35:3094-3102(1994)

Patent=US5643782
Usha P. Andley, Timothy P. Fleming;
Immortalized epithelial cell lines.
Patent number US5643782, 01-Jul-1997

PubMed=14578405; DOI=10.1167/iovs.03-0556
Shuh-Tuan Wang-Su, Ashley L. McCormack, Shao-Jun Yang, Matthew Robert Hosler, April Mixon, Michael A. Riviere, Phillip A. Wilmarth, Usha P. Andley, Donita Garland, Hong Li, Larry L. David, Betty Jean Wagner;
Proteome analysis of lens epithelia, fibers, and the HLE B-3 cell line.
Invest. Ophthalmol. Vis. Sci. 44:4829-4836(2003)

Cross-references
Cell line collections (Providers) ATCC; CRL-3603
ATCC; CRL-11421 - Discontinued
Cell line databases/resources CLO; CLO_0001812
Anatomy/cell type resources BTO; BTO_0002221
Biological sample resources BioSample; SAMN03471336
Encyclopedic resources Wikidata; Q54752060
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number21