ID   B-3
AC   CVCL_6367
AS   CVCL_8482
SY   HLE-B3; HLE B-3; HLEB-3; HLEB3; HLEC-B3
DR   BTO; BTO_0002221
DR   CLO; CLO_0001812
DR   ATCC; CRL-3603
DR   ATCC; CRL-11421
DR   BioSample; SAMN03471336
DR   Wikidata; Q54752060
RX   Patent=US5643782;
RX   PubMed=8206728;
RX   PubMed=14578405;
CC   Group: Patented cell line.
CC   Problematic cell line: Possibly misidentified. Presence of a Y chromosome in cell line that was thought to be of female origin (STR profile).
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11421.
CC   Transformant: Ad12-SV40 hybrid virus.
CC   Discontinued: ATCC; CRL-11421; true.
CC   Derived from site: In situ; Eye, ocular lens, epithelium; UBERON=UBERON_0001803.
CC   Cell type: Epithelial cell of ocular lens; CL=CL_0002224.
ST   Source(s): ATCC=CRL-3603
ST   Amelogenin: X,Y
ST   CSF1PO: 11
ST   D13S317: 11
ST   D16S539: 11,12
ST   D5S818: 9,11
ST   D7S820: 11
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 14,19
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   5-12M
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 21
//
RX   PubMed=8206728;
RA   Andley, Usha P.
RA   Rhim, Johng Sik
RA   Chylack, Leo T. Jr.
RA   Fleming, Timothy P.
RT   "Propagation and immortalization of human lens epithelial cells in
RT   culture.";
RL   Invest. Ophthalmol. Vis. Sci. 35:3094-3102(1994).
//
RX   PubMed=14578405; DOI=10.1167/iovs.03-0556;
RA   Wang-Su, Shuh-Tuan
RA   McCormack, Ashley L.
RA   Yang, Shao-Jun
RA   Hosler, Matthew Robert
RA   Mixon, April
RA   Riviere, Michael A.
RA   Wilmarth, Phillip A.
RA   Andley, Usha P.
RA   Garland, Donita
RA   Li, Hong
RA   David, Larry L.
RA   Wagner, Betty Jean
RT   "Proteome analysis of lens epithelia, fibers, and the HLE B-3 cell
RT   line.";
RL   Invest. Ophthalmol. Vis. Sci. 44:4829-4836(2003).
//
RX   Patent=US5643782;
RA   Andley, Usha P.
RA   Fleming, Timothy P.
RT   "Immortalized epithelial cell lines.";
RL   Patent number US5643782, 01-Jul-1997.
//