Cellosaurus cell line GT1-3 (CVCL

Cellosaurus GT1-3 (CVCL_6237)

Cross-references
Cell line name	GT1-3
Accession	CVCL_6237
Secondary accession	CVCL_8220
Resource Identification Initiative	To cite this cell line use: GT1-3 (RRID:CVCL_6237)
Comments	Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40). Misspelling: GTI-3; Note=Occasionally. Derived from site: In situ; Brain, hypothalamus; UBERON=UBERON_0001898. Cell type: GnRH neuron; CL=CL_0011111.
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: (C57BL/6J x BALB/cJ) F2 transgenic with rat Gnrh1 promoter-Tg(SV40).
Hierarchy	Parent: CVCL_6235 (GT1)
Category	Transformed cell line
Publications	PubMed=2196069; DOI=10.1016/0896-6273(90)90028-E Pamela L. Mellon, Jolene J. Windle, Paul C. Goldsmith, Cheryl A. Padula, James L. Roberts, Richard I. Weiner; Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron 5:1-10(1990) PubMed=1714837; DOI=10.1210/endo-129-3-1584 William C. Wetsel, Pamela L. Mellon, Richard I. Weiner, Andres Negro-Vilar; Metabolism of pro-luteinizing hormone-releasing hormone in immortalized hypothalamic neurons. Endocrinology 129:1584-1595(1991) PubMed=18406727; DOI=10.1016/1043-2760(95)00228-6 Margaret E. Wierman, Zhao-Qin Fang, Jadwiga K. Kepa; GnRH gene expression in neuronal cell lines. Trends Endocrinol. Metab. 7:60-65(1996)
Encyclopedic resources	Wikidata; Q54871827
Entry history
Entry creation	04-Apr-2012
Last entry update	14-Aug-2025
Version number	15