Cellosaurus cell line CHO-xrs-4 (CVCL

Cellosaurus CHO-xrs-4 (CVCL_5A39)

Cross-references
Cell line name	CHO-xrs-4
Synonyms	xrs-4; xrs4
Accession	CVCL_5A39
Resource Identification Initiative	To cite this cell line use: CHO-xrs-4 (RRID:CVCL_5A39)
Comments	Characteristics: Sensitive to X-ray. Has a defect in double-strand break rejoining (PubMed=6513971). Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE). Derived from site: In situ; Ovary; UBERON=UBERON_0000992. Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy	Parent: CVCL_0214 (CHO-K1)
Sex of cell	Female
Age at sampling	Adult
Category	Spontaneously immortalized cell line
Publications	PubMed=6197643; DOI=10.1016/0167-8817(83)90026-3 Penelope Ann Jeggo, Lynn M. Kemp; X-ray-sensitive mutants of Chinese hamster ovary cell line. Isolation and cross-sensitivity to other DNA-damaging agents. Mutat. Res. 112:313-327(1983) PubMed=6513971; DOI=10.1016/0167-8817(84)90037-3 Lynn M. Kemp, Steven G. Sedgwick, Penelope Ann Jeggo; X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining. Mutat. Res. 132:189-196(1984) PubMed=2564870; DOI=10.1080/09553008914550651 Julie Denekamp, Gordon Francis Whitmore, Penelope Ann Jeggo; Biphasic survival curves for XRS radiosensitive cells: subpopulations or transient expression of repair competence? Int. J. Radiat. Biol. 55:605-617(1989) PubMed=9032253; DOI=10.1128/mcb.17.3.1264; PMCID=PMC231851 Belinda K. Singleton, Anne Priestley, Herdis Steingrimsdottir, David Gell, Tracy Blunt, Stephen Philip Jackson, Alan R. Lehmann, Penelope Ann Jeggo; Molecular and biochemical characterization of xrs mutants defective in Ku80. Mol. Cell. Biol. 17:1264-1273(1997)
Encyclopedic resources	Wikidata; Q54813130
Entry history
Entry creation	14-Dec-2015
Last entry update	19-Dec-2024
Version number	8