Cellosaurus logo
expasy logo

Cellosaurus Trex1-/- MEF (CVCL_5A06)

[Text version]
Cell line name Trex1-/- MEF
Synonyms MEF Trex1 KO; Trex1 KO cells; Trex1 KO
Accession CVCL_5A06
Resource Identification Initiative To cite this cell line use: Trex1-/- MEF (RRID:CVCL_5A06)
Comments Knockout cell: Method=Gene-targeted KO mouse; MGI; MGI:1328317; Trex1.
Derived from site: In situ; Embryo; UBERON=UBERON_0000922.
Cell type: Fibroblast; CL=CL_0000057.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: 129P2/OlaHsd.
Sex of cell Sex unspecified
Age at sampling Embryo
Category Spontaneously immortalized cell line
Publications

PubMed=15254239; DOI=10.1128/mcb.24.15.6719-6727.2004; PMCID=PMC444847
Morita M., Stamp G.W.H., Robins P., Dulic A., Rosewell I., Hrivnak G., Daly G., Lindahl T.R., Barnes D.E.
Gene-targeted mice lacking the Trex1 (DNase III) 3'->5' DNA exonuclease develop inflammatory myocarditis.
Mol. Cell. Biol. 24:6719-6727(2004)

PubMed=18045533; DOI=10.1016/j.cell.2007.10.017
Yang Y.-G., Lindahl T.R., Barnes D.E.
Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease.
Cell 131:873-886(2007)

Cross-references
Cell line collections (Providers) CancerTools; 151558
ECACC; 12021509 - Discontinued
Ximbio; 151558
Encyclopedic resources Wikidata; Q54973004
Entry history
Entry creation14-Dec-2015
Last entry update10-Sep-2024
Version number8