Cellosaurus cell line Trex1-/- MEF (CVCL

Cross-references
Cell line name	Trex1-/- MEF
Synonyms	MEF Trex1 KO; Trex1 KO cells; Trex1 KO
Accession	CVCL_5A06
Resource Identification Initiative	To cite this cell line use: Trex1-/- MEF (RRID:CVCL_5A06)
Comments	Knockout cell: Method=Gene-targeted KO mouse; MGI; MGI:1328317; Trex1. Derived from site: In situ; Embryo; UBERON=UBERON_0000922. Cell type: Fibroblast; CL=CL_0000057.
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: 129P2/OlaHsd.
Sex of cell	Sex unspecified
Age at sampling	Embryo
Category	Spontaneously immortalized cell line
Publications	PubMed=15254239; DOI=10.1128/mcb.24.15.6719-6727.2004; PMCID=PMC444847 Masashi Morita, Gordon W.H. Stamp, Peter Robins, Anna Dulic, Ian Rosewell, Geza Hrivnak, Graham Daly, Tomas Robert Lindahl, Deborah E. Barnes; Gene-targeted mice lacking the Trex1 (DNase III) 3'->5' DNA exonuclease develop inflammatory myocarditis. Mol. Cell. Biol. 24:6719-6727(2004) PubMed=18045533; DOI=10.1016/j.cell.2007.10.017 Yun-Gui Yang, Tomas Robert Lindahl, Deborah E. Barnes; Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell 131:873-886(2007)
Cell line collections (Providers)	CancerTools; 151558 ECACC; 12021509 - Discontinued Ximbio; 151558
Encyclopedic resources	Wikidata; Q54973004
Entry history
Entry creation	14-Dec-2015
Last entry update	10-Sep-2024
Version number	8