ID   Trex1-/- MEF
AC   CVCL_5A06
SY   MEF Trex1 KO; Trex1 KO cells; Trex1 KO
DR   CancerTools; 151558
DR   ECACC; 12021509
DR   Wikidata; Q54973004
DR   Ximbio; 151558
RX   PubMed=15254239;
RX   PubMed=18045533;
CC   Knockout cell: Method=Gene-targeted KO mouse; MGI; MGI:1328317; Trex1.
CC   Discontinued: ECACC; 12021509; true.
CC   Derived from site: In situ; Embryo; UBERON=UBERON_0000922.
CC   Cell type: Fibroblast; CL=CL_0000057.
CC   Breed/subspecies: 129P2/OlaHsd.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Sex unspecified
AG   Embryo
CA   Spontaneously immortalized cell line
DT   Created: 14-12-15; Last updated: 10-09-24; Version: 8
//
RX   PubMed=18045533; DOI=10.1016/j.cell.2007.10.017;
RA   Yang, Yun-Gui
RA   Lindahl, Tomas Robert
RA   Barnes, Deborah E.
RT   "Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint
RT   activation and autoimmune disease.";
RL   Cell 131:873-886(2007).
//
RX   PubMed=15254239; DOI=10.1128/mcb.24.15.6719-6727.2004; PMCID=PMC444847;
RA   Morita, Masashi
RA   Stamp, Gordon W.H.
RA   Robins, Peter
RA   Dulic, Anna
RA   Rosewell, Ian
RA   Hrivnak, Geza
RA   Daly, Graham
RA   Lindahl, Tomas Robert
RA   Barnes, Deborah E.
RT   "Gene-targeted mice lacking the Trex1 (DNase III) 3'->5' DNA
RT   exonuclease develop inflammatory myocarditis.";
RL   Mol. Cell. Biol. 24:6719-6727(2004).
//