ID   Trex1-/- MEF
AC   CVCL_5A06
SY   MEF Trex1 KO; Trex1 KO cells; Trex1 KO
DR   CancerTools; 151558
DR   ECACC; 12021509
DR   Wikidata; Q54973004
DR   Ximbio; 151558
RX   PubMed=15254239;
RX   PubMed=18045533;
CC   Knockout cell: Method=Gene-targeted KO mouse; MGI; MGI:1328317; Trex1.
CC   Derived from sampling site: Cell type=Fibroblast.
CC   Breed/subspecies: 129P2/OlaHsd.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Sex unspecified
AG   Embryo
CA   Spontaneously immortalized cell line
DT   Created: 14-12-15; Last updated: 21-03-23; Version: 6
RX   PubMed=15254239; DOI=10.1128/mcb.24.15.6719-6727.2004;
RA   Morita M., Stamp G.W.H., Robins P., Dulic A., Rosewell I., Hrivnak G.,
RA   Daly G., Lindahl T.R., Barnes D.E.;
RT   "Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA
RT   exonuclease develop inflammatory myocarditis.";
RL   Mol. Cell. Biol. 24:6719-6727(2004).
RX   PubMed=18045533; DOI=10.1016/j.cell.2007.10.017;
RA   Yang Y.-G., Lindahl T.R., Barnes D.E.;
RT   "Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint
RT   activation and autoimmune disease.";
RL   Cell 131:873-886(2007).