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Cellosaurus KB-ChR-8-5-11 (CVCL_5997)

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Cell line name KB-ChR-8-5-11
Synonyms KB-8-5-11
Accession CVCL_5997
Resource Identification Initiative To cite this cell line use: KB-ChR-8-5-11 (RRID:CVCL_5997)
Comments Problematic cell line: Contaminated. Ancestral cell line (KB) has been shown to be a HeLa derivative.
Population: African American.
Characteristics: Resistant to paclitaxel and many other chemotherapy agents as it overexpresses the P-glycoprotein (ABCB1).
Selected for resistance to: ChEBI; CHEBI_23359; Colchicine.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5994 (KB-ChR-8-5)
Children:
CVCL_M125 (KB-ChR-8-5-11-24)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Publications

PubMed=3856953; DOI=10.1007/BF01534700
Shin-ichi Akiyama, Antonio Fojo, John A. Hanover, Ira Pastan, Michael Marc Gottesman;
Isolation and genetic characterization of human KB cell lines resistant to multiple drugs.
Somat. Cell Mol. Genet. 11:117-126(1985)

PubMed=3711108; DOI=10.1016/S0021-9258(19)57466-X
Ding-Wu Shen, Carol O. Cardarelli, Jaulang Hwang, Marilyn Cornwell, Nancy Richert, Shunsuke Ishii, Ira Pastan, Michael Marc Gottesman;
Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.
J. Biol. Chem. 261:7762-7770(1986)

PubMed=2897240; DOI=10.1016/0092-8674(88)90568-5
Kyunghee Choi, Chang-Jie Chen, Michael Kriegler, Igor B. Roninson;
An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene.
Cell 53:519-529(1988)

PubMed=24403508
Ben Doherty, Denise Lawlor, Jean-Pierre Gillet, Michael Marc Gottesman, John J. O'Leary, Britta Stordal;
Collateral sensitivity to cisplatin in KB-8-5-11 drug-resistant cancer cells.
Anticancer Res. 34:503-507(2014)

Cross-references
Encyclopedic resources Wikidata; Q54899553
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number20