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Cellosaurus KB-ChR-8-5 (CVCL_5994)

[Text version]
Cell line name KB-ChR-8-5
Synonyms KB-CH[R]-8-5; KBCh(R)-8-5; KB-8-5; KB 8-5; KB8-5
Accession CVCL_5994
Resource Identification Initiative To cite this cell line use: KB-ChR-8-5 (RRID:CVCL_5994)
Comments Problematic cell line: Contaminated. Ancestral cell line (KB) has been shown to be a HeLa derivative.
Population: African American.
Selected for resistance to: ChEBI; CHEBI_23359; Colchicine.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E3EU (KB-ChR-8)
Children:
CVCL_5997 (KB-ChR-8-5-11)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Web pages Provider; NIH OTT; E-005-2006/0-4; https://web.archive.org/web/20150922074206/http://www.ott.nih.gov/erma/multidrug-resistant-epidermal-carcinoma-cell-line-kb-8-5-and-kb-8-11
Publications

PubMed=3856953; DOI=10.1007/BF01534700
Shin-ichi Akiyama, Antonio Fojo, John A. Hanover, Ira Pastan, Michael Marc Gottesman;
Isolation and genetic characterization of human KB cell lines resistant to multiple drugs.
Somat. Cell Mol. Genet. 11:117-126(1985)

PubMed=3711108; DOI=10.1016/S0021-9258(19)57466-X
Ding-Wu Shen, Carol O. Cardarelli, Jaulang Hwang, Marilyn Cornwell, Nancy Richert, Shunsuke Ishii, Ira Pastan, Michael Marc Gottesman;
Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.
J. Biol. Chem. 261:7762-7770(1986)

PubMed=2897240; DOI=10.1016/0092-8674(88)90568-5
Kyunghee Choi, Chang-Jie Chen, Michael Kriegler, Igor B. Roninson;
An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene.
Cell 53:519-529(1988)

PubMed=7865904
Xiao-Ping Zhang, Mary K. Ritke, Jack Charles Yalowich, Marilyn L. Slovak, Jennifer Pelkey Ho, Karen I. Collins, Tami Annable, Robert John Arceci, Frederick E. Durr, Lee M. Greenberger;
P-glycoprotein mediates profound resistance to bisantrene.
Oncol. Res. 6:291-301(1994)

Cross-references
Anatomy/cell type resources BTO; BTO_0003919
Encyclopedic resources Wikidata; Q54899552
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number20