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Cellosaurus KB-ChR-8-5 (CVCL_5994)

[Text version]
Cell line name KB-ChR-8-5
Synonyms KB-CH[R]-8-5; KBCh(R)-8-5; KB-8-5; KB 8-5; KB8-5
Accession CVCL_5994
Resource Identification Initiative To cite this cell line use: KB-ChR-8-5 (RRID:CVCL_5994)
Comments Problematic cell line: Contaminated. Grand-parent cell line (KB) has been shown to be a HeLa derivative.
Population: African American.
Selected for resistance to: ChEBI; CHEBI:23359; Colchicine.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2088 (KB-3-1)
CVCL_5997 (KB-ChR-8-5-11)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Web pages http://www.ott.nih.gov/erma/multidrug-resistant-epidermal-carcinoma-cell-line-kb-8-5-and-kb-8-11

PubMed=3856953; DOI=10.1007/BF01534700
Akiyama S.-i., Fojo A.T., Hanover J.A., Pastan I., Gottesman M.M.
Isolation and genetic characterization of human KB cell lines resistant to multiple drugs.
Somat. Cell Mol. Genet. 11:117-126(1985)

PubMed=3711108; DOI=10.1016/S0021-9258(19)57466-X
Shen D.-W., Cardarelli C., Hwang J., Cornwell M., Richert N., Ishii S., Pastan I., Gottesman M.M.
Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.
J. Biol. Chem. 261:7762-7770(1986)

Zhang X.P., Ritke M.K., Yalowich J.C., Slovak M.L., Ho J.P., Collins K.I., Annable T., Arceci R.J., Durr F.E., Greenberger L.M.
P-glycoprotein mediates profound resistance to bisantrene.
Oncol. Res. 6:291-301(1994)

Anatomy/cell type resources BTO; BTO:0003919
Encyclopedic resources Wikidata; Q54899552
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number18