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Cellosaurus JHU-028 (CVCL_5992)

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Cell line name JHU-028
Synonyms JHU 028; JHU028; SCC028; HNSCC 028; O28; Johns Hopkins University-028
Accession CVCL_5992
Resource Identification Initiative To cite this cell line use: JHU-028 (RRID:CVCL_5992)
Comments Problematic cell line: Contaminated. Shown to be a A-549 derivative (PubMed=21868764). Originally thought to originate from a base of tongue squamous cell carcinoma.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00406.
Population: Caucasian.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (DepMap=ACH-002337).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (DepMap=ACH-002337).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): PubMed=21868764

Markers:
AmelogeninX
CSF1PO10,12
D5S81813
D7S8208,11
D13S31711
D16S53911,12
TH018
TPOX8,11
vWA14

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=12925955; DOI=10.1002/ijc.11341
Khalid M. Minhas, Bhuvanesh Singh, Wei-Wen Jiang, David Sidransky, Joseph A. Califano 3rd;
Spindle assembly checkpoint defects and chromosomal instability in head and neck squamous cell carcinoma.
Int. J. Cancer 107:46-52(2003)

PubMed=12963126; DOI=10.1016/S0304-3835(03)00344-6
Mohammad Obaidul Hoque, Shahnaz Begum, Matthias Sommer, Taekyeol Lee, Barry Trink, Edward Ratovitski, David Sidransky;
PUMA in head and neck cancer.
Cancer Lett. 199:75-81(2003)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5992
Cell_Model_Passport; SIDM00902
DepMap; ACH-002337
Anatomy/cell type resources BTO; BTO_0006404
Biological sample resources BioSample; SAMN03151610
Chemistry resources GDSC; 1298154
PharmacoDB; JHU028_696_2019
Encyclopedic resources Wikidata; Q54898675
Gene expression databases ArrayExpress; E-MTAB-3610
Proteomic databases PRIDE; PXD002132
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number26