ID   JHU-028
AC   CVCL_5992
SY   JHU 028; JHU028; SCC028; HNSCC 028; O28; Johns Hopkins University-028
DR   BTO; BTO:0006404
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03151610
DR   cancercelllines; CVCL_5992
DR   Cell_Model_Passport; SIDM00902
DR   DepMap; ACH-002337
DR   EGA; EGAS00001000978
DR   GDSC; 1298154
DR   PharmacoDB; JHU028_696_2019
DR   PRIDE; PXD002132
DR   Wikidata; Q54898675
RX   PubMed=12925955;
RX   PubMed=12963126;
RX   PubMed=21868764;
CC   Problematic cell line: Contaminated. Shown to be a A-549 derivative (PubMed=21868764). Originally thought to originate from a base of tongue squamous cell carcinoma.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00406.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (DepMap=ACH-002337).
CC   Sequence variation: Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (DepMap=ACH-002337).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
ST   Source(s): PubMed=21868764
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 11
ST   D16S539: 11,12
ST   D5S818: 13
ST   D7S820: 8,11
ST   TH01: 8
ST   TPOX: 8,11
ST   vWA: 14
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0023 ! A-549
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 24
RX   PubMed=12925955; DOI=10.1002/ijc.11341;
RA   Minhas K.M., Singh B., Jiang W.-W., Sidransky D., Califano J.A. III;
RT   "Spindle assembly checkpoint defects and chromosomal instability in
RT   head and neck squamous cell carcinoma.";
RL   Int. J. Cancer 107:46-52(2003).
RX   PubMed=12963126; DOI=10.1016/S0304-3835(03)00344-6;
RA   Hoque M.O., Begum S., Sommer M., Lee T., Trink B., Ratovitski E.,
RA   Sidransky D.;
RT   "PUMA in head and neck cancer.";
RL   Cancer Lett. 199:75-81(2003).
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690;
RA   Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C.,
RA   Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G.,
RA   Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.;
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).