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Cellosaurus JHU-012 (CVCL_5987)

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Cell line name JHU-012
Synonyms JHU 012; JHU-O12; JHU012; SCC012; HNSCC 012; O12; 012; Johns Hopkins University-012
Accession CVCL_5987
Resource Identification Initiative To cite this cell line use: JHU-012 (RRID:CVCL_5987)
Comments Problematic cell line: Contaminated. Shown to be a JHU-022 derivative (PubMed=21868764). Originally thought to originate from the lymph node of a metastatic floor of mouth carcinoma in a 62 year old female patient.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00403.
Population: Caucasian.
Misspelling: JHU-112; Cosmic=1530746.
Derived from site: In situ; Larynx; UBERON=UBERON_0001737.
Disease Laryngeal squamous cell carcinoma (NCIt: C4044)
Squamous cell carcinoma of the larynx (ORDO: Orphanet_494550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5991 (JHU-022)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2720; PubMed=21868764

Markers:
AmelogeninX,Y
CSF1PO10
D5S81812,13
D7S8209,10
D13S31711
D16S53912
TH016
TPOX8
vWA14,16

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=12925955; DOI=10.1002/ijc.11341
Khalid M. Minhas, Bhuvanesh Singh, Wei-Wen Jiang, David Sidransky, Joseph A. Califano 3rd;
Spindle assembly checkpoint defects and chromosomal instability in head and neck squamous cell carcinoma.
Int. J. Cancer 107:46-52(2003)

PubMed=12963126; DOI=10.1016/S0304-3835(03)00344-6
Mohammad Obaidul Hoque, Shahnaz Begum, Matthias Sommer, Taekyeol Lee, Barry Trink, Edward Ratovitski, David Sidransky;
PUMA in head and neck cancer.
Cancer Lett. 199:75-81(2003)

PubMed=17848307; DOI=10.1016/j.ijrobp.2007.04.082
Wendell Gray Yarbrough, Amy Whigham, Brandee Brown, Michael Roach, Robbert J.C. Slebos;
Phosphoinositide kinase-3 status associated with presence or absence of human papillomavirus in head and neck squamous cell carcinomas.
Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

Cross-references
Cell line collections (Providers) ATCC; CRL-2720 - Discontinued
Biological sample resources BioSample; SAMN03151804
Encyclopedic resources Wikidata; Q54898668
Polymorphism and mutation databases Cosmic; 1122669
Cosmic; 1530746
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number22