ID   JHU-012
AC   CVCL_5987
SY   JHU 012; JHU-O12; JHU012; SCC012; HNSCC 012; O12; 012; Johns Hopkins University-012
DR   ATCC; CRL-2720
DR   BioSample; SAMN03151804
DR   Cosmic; 1122669
DR   Cosmic; 1530746
DR   Wikidata; Q54898668
RX   PubMed=12925955;
RX   PubMed=12963126;
RX   PubMed=17848307;
RX   PubMed=21868764;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a JHU-022 derivative (PubMed=21868764). Originally thought to originate from the lymph node of a metastatic floor of mouth carcinoma in a 62 year old female patient.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00403.
CC   Population: Caucasian.
CC   Misspelling: JHU-112; Cosmic=1530746.
CC   Discontinued: ATCC; CRL-2720; true.
CC   Derived from site: In situ; Larynx; UBERON=UBERON_0001737.
ST   Source(s): ATCC=CRL-2720; PubMed=21868764
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 11
ST   D16S539: 12
ST   D5S818: 12,13
ST   D7S820: 9,10
ST   TH01: 6
ST   TPOX: 8
ST   vWA: 14,16
DI   NCIt; C4044; Laryngeal squamous cell carcinoma
DI   ORDO; Orphanet_494550; Squamous cell carcinoma of the larynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_5991 ! JHU-022
SX   Male
AG   53Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 22
//
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662;
RA   Zhao, Mei
RA   Sano, Daisuke
RA   Pickering, Curtis R.
RA   Jasser, Samar A.
RA   Henderson, Ying C.
RA   Clayman, Gary L.
RA   Sturgis, Erich M.
RA   Ow, Thomas J.
RA   Lotan, Reuben
RA   Carey, Thomas E.
RA   Sacks, Peter G.
RA   Grandis, Jennifer Rubin
RA   Sidransky, David
RA   Heldin, Nils-Erik
RA   Myers, Jeffrey N.
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).
//
RX   PubMed=12925955; DOI=10.1002/ijc.11341;
RA   Minhas, Khalid M.
RA   Singh, Bhuvanesh
RA   Jiang, Wei-Wen
RA   Sidransky, David
RA   Califano, Joseph A. 3rd
RT   "Spindle assembly checkpoint defects and chromosomal instability in
RT   head and neck squamous cell carcinoma.";
RL   Int. J. Cancer 107:46-52(2003).
//
RX   PubMed=17848307; DOI=10.1016/j.ijrobp.2007.04.082;
RA   Yarbrough, Wendell Gray
RA   Whigham, Amy
RA   Brown, Brandee
RA   Roach, Michael
RA   Slebos, Robbert J.C.
RT   "Phosphoinositide kinase-3 status associated with presence or absence
RT   of human papillomavirus in head and neck squamous cell carcinomas.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007).
//
RX   PubMed=12963126; DOI=10.1016/S0304-3835(03)00344-6;
RA   Hoque, Mohammad Obaidul
RA   Begum, Shahnaz
RA   Sommer, Matthias
RA   Lee, Taekyeol
RA   Trink, Barry
RA   Ratovitski, Edward
RA   Sidransky, David
RT   "PUMA in head and neck cancer.";
RL   Cancer Lett. 199:75-81(2003).
//