Cellosaurus cell line FAMPAC (CVCL

Cellosaurus FAMPAC (CVCL_5749)

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Cell line name

FAMPAC

Synonyms

FamPAC; Fampac; PA-CLS-13; PA-CLS 13

Accession

CVCL_5749

Resource Identification Initiative

To cite this cell line use: FAMPAC (RRID:CVCL_5749)

Comments

Population: Caucasian.
Doubling time: 24-48 hours (PubMed=15112280).
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.

Sequence variations

Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (CLS=300309).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Unspecified (PubMed=15112280).

HLA typing

Source: CLS=300309

Class I
HLA-A	A*03:01:01
HLA-B	B*27:05:01
HLA-C	C*15:02:01
Class II
HLA-DP	DPB1*03.01:01
HLA-DQ	DQA1*05:05:01
	DQB1*03:01:01
HLA-DR	DRB1*12:01:01

Disease

Pancreatic ductal adenocarcinoma (NCIt: C9120)
Hereditary pancreatic carcinoma (NCIt: C43298)
Familial pancreatic carcinoma (ORDO: Orphanet_1333)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Children:

CVCL_5750 (FAMPAC-A)

Sex of cell

Female

Age at sampling

43Y

Category

Cancer cell line

STR profile

Source(s): CLS=300309

Markers:

Amelogenin	X
CSF1PO	10
D3S1358	16,17
D5S818	10,11
D7S820	11
D13S317	8
D16S539	14
D18S51	15
D21S11	32.2
Penta D	11
Penta E	12,13
vWA	15

Publications

PubMed=15112280; DOI=10.1002/cncr.20193
Sven Eisold, Eduard Ryschich, Michael Linnebacher, Thomas Giese, Dirk Nauheimer, Anja Wild, Detlef K. Bartsch, Markus Wolfgang Buchler, Jan Schmidt;
Characterization of FAMPAC, a newly identified human pancreatic carcinoma cell line with a hereditary background.
Cancer 100:1978-1986(2004)

DOI=10.22029/jlupub-12385
Laura Oberlin;
Treatment of pancreatic carcinoma cell lines in vitro and vivo with a monoclonal antibody against the transferrin receptor.
Thesis VMD (2009); Justus-Liebig-Universitat Giessen; Giessen; Germany

PubMed=22753594; DOI=10.1158/1078-0432.CCR-12-0827; PMCID=PMC3513499
Yun-Feng Cui, Jacqueline A. Brosnan-Cashman, Amanda L. Blackford, Surojit Sur, Ralph H. Hruban, Kenneth Wayne Kinzler, Bert Vogelstein, Anirban Maitra, Luis Alberto Diaz Jr., Christine A. Iacobuzio-Donahue, James Richard Eshleman;
Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity.
Clin. Cancer Res. 18:6519-6530(2012)

DOI=10.4172/2324-9293.1000104
Markus Udo Wagenhauser, Felix Ruckert, Marco Niedergethmann, Robert Grutzmann, Hans-Detlev Saeger;
Distribution of characteristic mutations in native ductal adenocarcinoma of the pancreas and pancreatic cancer cell lines.
Cell Biol. Res. Ther. 2:1000104.1-1000104.5(2013)

Cross-references

Cell line collections (Providers)

CLS; 300309

Cell line databases/resources

cancercelllines; CVCL_5749

Encyclopedic resources

Wikidata; Q54833235

Polymorphism and mutation databases

Cosmic; 2664044
IARC_TP53; 20736

Entry history

Entry creation

04-Apr-2012

Last entry update

10-Apr-2025

Version number