| Cell line name |
FAMPAC |
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| Synonyms |
FamPAC; Fampac; PA-CLS-13; PA-CLS 13 |
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| Accession |
CVCL_5749 |
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| Resource Identification Initiative |
To cite this cell line use: FAMPAC (RRID:CVCL_5749) |
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| Comments |
Population: Caucasian.
Doubling time: 24-48 hours (PubMed=15112280).
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264. |
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| Sequence variations |
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (CLS=300309).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Unspecified (PubMed=15112280).
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| HLA typing |
Source: CLS=300309
| Class I | | HLA-A | A*03:01:01 | | HLA-B | B*27:05:01 | | HLA-C | C*15:02:01 | | Class II | | HLA-DP | DPB1*03.01:01 | | HLA-DQ | DQA1*05:05:01 | | DQB1*03:01:01 | | HLA-DR | DRB1*12:01:01 |
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| Disease |
Pancreatic ductal adenocarcinoma (NCIt: C9120)
Hereditary pancreatic carcinoma (NCIt: C43298)
Familial pancreatic carcinoma (ORDO: Orphanet_1333) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Children:
|
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| Sex of cell |
Female |
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| Age at sampling |
43Y |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): CLS=300309
Markers:
Run an STR similarity search on this cell line |
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| Publications | PubMed=15112280; DOI=10.1002/cncr.20193
Eisold S., Ryschich E., Linnebacher M., Giese T., Nauheimer D., Wild A., Bartsch D.K., Buchler M.W., Schmidt J.
Characterization of FAMPAC, a newly identified human pancreatic carcinoma cell line with a hereditary background.
Cancer 100:1978-1986(2004) CLPUB00416
Oberlin L.
Treatment of pancreatic carcinoma cell lines in vitro and vivo with a monoclonal antibody against the transferrin receptor.
Thesis VMD (2009), Justus-Liebig-Universitat Giessen, Germany PubMed=22753594; DOI=10.1158/1078-0432.CCR-12-0827
Cui Y.-F., Brosnan-Cashman J.A., Blackford A.L., Sur S., Hruban R.H., Kinzler K.W., Vogelstein B., Maitra A., Diaz L.A. Jr., Iacobuzio-Donahue C.A., Eshleman J.R.
Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity.
Clin. Cancer Res. 18:6519-6530(2012) DOI=10.4172/2324-9293.1000104
Wagenhauser M.U., Ruckert F., Niedergethmann M., Grutzmann R., Saeger H.-D.
Distribution of characteristic mutations in native ductal adenocarcinoma of the pancreas and pancreatic cancer cell lines.
Cell Biol. Res. Ther. 2:1000104.1-1000104.5(2013) |
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| Cross-references |
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| Cell line collections (Providers) |
CLS; 300309
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| Cell line databases/resources |
cancercelllines; CVCL_5749
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| Encyclopedic resources |
Wikidata; Q54833235
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| Polymorphism and mutation databases |
Cosmic; 2664044
IARC_TP53; 20736
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| Entry history |
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| Entry creation | 04-Apr-2012 |
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| Last entry update | 02-May-2024 |
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| Version number | 20 |
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