ID   FAMPAC
AC   CVCL_5749
SY   FamPAC; Fampac; PA-CLS-13; PA-CLS 13
DR   cancercelllines; CVCL_5749
DR   CLS; 300309
DR   Cosmic; 2664044
DR   IARC_TP53; 20736
DR   Wikidata; Q54833235
RX   CelloPub=CLPUB00416;
RX   DOI=10.4172/2324-9293.1000104;
RX   PubMed=15112280;
RX   PubMed=22753594;
CC   Population: Caucasian.
CC   Doubling time: 24-48 hours (PubMed=15112280).
CC   HLA typing: A*03:01:01; B*27:05:01; C*15:02:01; DPB1*03.01:01; DQA1*05:05:01; DQB1*03:01:01; DRB1*12:01:01 (CLS=300309).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (CLS=300309).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Unspecified (PubMed=15112280).
CC   Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
ST   Source(s): CLS=300309
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 8
ST   D16S539: 14
ST   D18S51: 15
ST   D21S11: 32.2
ST   D3S1358: 16,17
ST   D5S818: 10,11
ST   D7S820: 11
ST   Penta D: 11
ST   Penta E: 12,13
ST   vWA: 15
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
DI   NCIt; C43298; Hereditary pancreatic carcinoma
DI   ORDO; Orphanet_1333; Familial pancreatic carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   43Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 20
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RX   CelloPub=CLPUB00416;
RA   Oberlin L.;
RT   "Treatment of pancreatic carcinoma cell lines in vitro and vivo with a
RT   monoclonal antibody against the transferrin receptor.";
RL   Thesis VMD (2009), Justus-Liebig-Universitat Giessen, Germany.
//
RX   DOI=10.4172/2324-9293.1000104;
RA   Wagenhauser M.U., Ruckert F., Niedergethmann M., Grutzmann R.,
RA   Saeger H.-D.;
RT   "Distribution of characteristic mutations in native ductal
RT   adenocarcinoma of the pancreas and pancreatic cancer cell lines.";
RL   Cell Biol. Res. Ther. 2:1000104.1-1000104.5(2013).
//
RX   PubMed=15112280; DOI=10.1002/cncr.20193;
RA   Eisold S., Ryschich E., Linnebacher M., Giese T., Nauheimer D.,
RA   Wild A., Bartsch D.K., Buchler M.W., Schmidt J.;
RT   "Characterization of FAMPAC, a newly identified human pancreatic
RT   carcinoma cell line with a hereditary background.";
RL   Cancer 100:1978-1986(2004).
//
RX   PubMed=22753594; DOI=10.1158/1078-0432.CCR-12-0827;
RA   Cui Y.-F., Brosnan-Cashman J.A., Blackford A.L., Sur S., Hruban R.H.,
RA   Kinzler K.W., Vogelstein B., Maitra A., Diaz L.A. Jr.,
RA   Iacobuzio-Donahue C.A., Eshleman J.R.;
RT   "Genetically defined subsets of human pancreatic cancer show unique in
RT   vitro chemosensitivity.";
RL   Clin. Cancer Res. 18:6519-6530(2012).
//