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Cellosaurus NALM-30 (CVCL_5668)

[Text version]
Cell line name NALM-30
Synonyms NALM30
Accession CVCL_5668
Resource Identification Initiative To cite this cell line use: NALM-30 (RRID:CVCL_5668)
Comments Population: Japanese.
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=34940123).
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (PubMed=10363160; PubMed=10576511).
Disease Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1 (NCIt: C82192)
Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2) (ORDO: Orphanet_589534)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_5665 ! NALM-27
CVCL_5666 ! NALM-28
CVCL_5669 ! NALM-31
CVCL_5670 ! NALM-32
Sex of cell Male
Age at sampling 39Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB1858

Markers:
AmelogeninX,Y
CSF1PO7,12
D5S81811,13
D7S8208,11
D13S3178
D16S5399
TH016,7
TPOX8
vWA17,18

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Publications

PubMed=9067587; DOI=10.1038/sj.leu.2400571
Uphoff C.C., MacLeod R.A.F., Denkmann S.A., Golub T.R., Borkhardt A., Janssen J.W.G., Drexler H.G.
Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.
Leukemia 11:441-447(1997)

PubMed=9680106; DOI=10.1016/S0145-2126(98)00050-2
Matsuo Y., Drexler H.G.
Establishment and characterization of human B cell precursor-leukemia cell lines.
Leuk. Res. 22:567-579(1998)

PubMed=10363160
Matsuo Y., Sugimoto A., Harashima A., Nishizaki C., Drexler H.G., Orita K.
Myeloperoxidase positive acute lymphoblastic leukemia cell lines, NALM-30, NALM-31 and NALM-32, carrying Philadelphia chromosome with biphenotypic characteristics.
Hum. Cell 11:221-230(1998)

PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9
Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.
ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.
Leuk. Res. 23:1055-1060(1999)

PubMed=34940123; DOI=10.3390/cimb43030149; PMCID=PMC8929001
Quentmeier H., Pommerenke C., Drexler H.G.
Molecular genetics of pre-B acute lymphoblastic leukemia sister cell lines during disease progression.
Curr. Issues Mol. Biol. 43:2147-2156(2021)

Cross-references
Cell line collections (Providers) JCRB; JCRB1858
Encyclopedic resources Wikidata; Q54907412
Gene expression databases ArrayExpress; E-MTAB-11038
ArrayExpress; E-MTAB-11039
Polymorphism and mutation databases Cosmic; 999735
Cosmic; 2491086
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number20