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Cellosaurus MCF-10AT (CVCL_5555)

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Cell line name MCF-10AT
Synonyms MCF10AT
Accession CVCL_5555
Resource Identification Initiative To cite this cell line use: MCF-10AT (RRID:CVCL_5555)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Omics: Proteomics; PTM; Glycoproteome.
Omics: Variations; CNV analysis.
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5554 (MCF-10A-neoT)
Children:
CVCL_5552 (MCF10DCIS.com)
Sex of cell Female
Age at sampling 36Y
Category Transformed cell line
Publications

PubMed=8546221; PMCID=PMC1861604
Peter J. Dawson, Sandra R. Wolman, Larry Tait, Gloria H. Heppner, Fred R. Miller;
MCF10AT: a model for the evolution of cancer from proliferative breast disease.
Am. J. Pathol. 148:313-319(1996)

PubMed=15375546; DOI=10.3892/ijo.25.4.961
Xin-Jian Peng, Du-Ri Yun, Konstantin Christov;
Breast cancer progression in MCF10A series of cell lines is associated with alterations in retinoic acid and retinoid X receptors and with differential response to retinoids.
Int. J. Oncol. 25:961-971(2004)

PubMed=20169162; DOI=10.1371/journal.pone.0009201; PMCID=PMC2821407
Mitsutaka Kadota, Howard H. Yang, Bianca P. Gomez, Misako Sato, Robert J. Clifford, Daoud Meerzaman, Barbara Karen Dunn, Lalage M. Wakefield, Maxwell P. Lee;
Delineating genetic alterations for tumor progression in the MCF10A series of breast cancer cell lines.
PLoS ONE 5:e9201.1-e9201.10(2010)

PubMed=24262153; DOI=10.1016/j.jprot.2013.11.006; PMCID=PMC3920745
Ten-Yang Yen, Nicole Haste, Leslie C. Timpe, Christina Litsakos-Cheung, Roger Yen, Bruce A. Macher;
Using a cell line breast cancer progression system to identify biomarker candidates.
J. Proteomics 96:173-183(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5555
IGRhCellID; MCF10AT
Encyclopedic resources Wikidata; Q54904299
Gene expression databases GEO; GSM498023
GEO; GSM498027
Polymorphism and mutation databases Progenetix; CVCL_5555
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number25