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Cellosaurus MCF10DCIS.com (CVCL_5552)

[Text version]

Cell line name MCF10DCIS.com
Accession CVCL_5552
Resource Identification Initiative To cite this cell line use: MCF10DCIS.com (RRID:CVCL_5552)
Comments Characteristics: Derived from a xenograft originating from MCF-10AT cells that were injected into severe combined immune-deficient mice.
Doubling time: 20.5 hours (PubMed=34238275).
Transfected with: HGNC; 5173; HRAS (with p.Gly12Val).
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Derived from sampling site: Breast; epithelium.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (PubMed=23401782).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5555 (MCF-10AT)
Sex of cell Female
Age at sampling 36Y
Category Transformed cell line

PubMed=10904098; DOI=10.1093/jnci/92.14.1185A
Miller F.R., Santner S.J., Tait L., Dawson P.J.
MCF10DCIS.com xenograft model of human comedo ductal carcinoma in situ.
J. Natl. Cancer Inst. 92:1185-1186(2000)

PubMed=18455123; DOI=10.1016/j.ccr.2008.03.007
Hu M., Yao J., Carroll D.K., Weremowicz S., Chen H.-Y., Carrasco D., Richardson A., Violette S.M., Nikolskaya T., Nikolsky Y., Bauerlein E.L., Hahn W.C., Gelman R.S., Allred C., Bissell M.J., Schnitt S., Polyak K.
Regulation of in situ to invasive breast carcinoma transition.
Cancer Cell 13:394-406(2008)

PubMed=23401782; DOI=10.1155/2013/872743
Barnabas N., Cohen D.
Phenotypic and molecular characterization of MCF10DCIS and SUM breast cancer cell lines.
Int. J. Breast Cancer 2013:872743.1-872743.16(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=34238275; DOI=10.1186/s12885-021-08511-2
Samson J., Derlipanska M., Zaheed O., Dean K.
Molecular and cellular characterization of two patient-derived ductal carcinoma in situ (DCIS) cell lines, ETCC-006 and ETCC-010.
BMC Cancer 21:790.1-790.20(2021)

Cell line databases/resources Lonza; 1619
Chemistry resources PharmacoDB; MCF10DCIS_com_892_2019
Encyclopedic resources Wikidata; Q54904447
Experimental variables resources EFO; EFO_0006643
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM271345
GEO; GSM271398
Metabolomic databases MetaboLights; MTBLS669
Polymorphism and mutation databases Cosmic; 1219447
Progenetix; CVCL_5552
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update22-Sep-2022
Version number25