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Cellosaurus OH-2 [Human plasma cell myeloma] (CVCL_5442)

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Cell line name OH-2 [Human plasma cell myeloma]
Synonyms OH2
Accession CVCL_5442
Resource Identification Initiative To cite this cell line use: OH-2 [Human plasma cell myeloma] (RRID:CVCL_5442)
Comments Characteristics: Produces IgG kappa.
Characteristics: IL6 dependent.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: Plasma cell; CL=CL_0000786.
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 52Y
Category Cancer cell line
Web pages Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=OH-2
Info; Keats Lab; -; https://www.keatslab.org/myeloma-cell-lines
Publications

PubMed=8062895; DOI=10.1111/j.1600-0609.1994.tb00176.x
Magne Borset, Anders Waage, Ole Lars Brekke, Eirik Helseth;
TNF and IL-6 are potent growth factors for OH-2, a novel human myeloma cell line.
Eur. J. Haematol. 53:31-37(1994)

DOI=10.1007/0-306-46877-8_4
Helena Jernberg-Wiklund, Kenneth Nilsson;
Multiple myeloma cell lines.
(In book chapter) Human cell culture. Vol. 3. Cancer cell lines part 3; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.81-155; Kluwer Academic Publishers; New York; USA (2000)

PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2
Hans Gunther Drexler, Yoshinobu Matsuo;
Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.
Leuk. Res. 24:681-703(2000)

PubMed=11154231; DOI=10.1182/blood.V97.2.516
Oyvind Hjertner, Henrik Hjorth-Hansen, Magne Borset, Carina Seidel, Anders Waage, Anders Sundan;
Bone morphogenetic protein-4 inhibits proliferation and induces apoptosis of multiple myeloma cells.
Blood 97:516-522(2001)

CLPUB00604
Sharon Chow;
Targeted capture and sequencing of immunoglobulin rearrangements in multiple myeloma to enable detection of minimal residual disease.
Thesis MSc (2017); University of Toronto; Toronto; Canada

PubMed=32123307; DOI=10.1038/s41375-020-0785-1; PMCID=PMC7483300
Vishesh Sarin, Katharine Yu, Ian D. Ferguson, Olivia Gugliemini, Matthew A. Nix, Byron Hann, Marina Sirota, Arun P. Wiita;
Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.
Leukemia 34:2754-2765(2020)

Cross-references
Encyclopedic resources Wikidata; Q54931884
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number20