ID   OH-2 [Human plasma cell myeloma]
AC   CVCL_5442
SY   OH2
DR   Wikidata; Q54931884
RX   CelloPub=CLPUB00604;
RX   DOI=10.1007/0-306-46877-8_4;
RX   PubMed=8062895;
RX   PubMed=10936422;
RX   PubMed=11154231;
RX   PubMed=32123307;
WW   https://www.keatslab.org/myeloma-cell-lines/hmcl-characteristics
WW   http://www.cells-talk.com/index.php/page/copelibrary?key=OH-2
CC   Characteristics: Produces IgG kappa.
CC   Characteristics: IL6 dependent.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   52Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 17
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RX   CelloPub=CLPUB00604;
RA   Chow S.;
RT   "Targeted capture and sequencing of immunoglobulin rearrangements
RT   in multiple myeloma to enable detection of minimal residual disease.";
RL   Thesis MSc (2017), University of Toronto, Canada.
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RX   DOI=10.1007/0-306-46877-8_4;
RA   Jernberg-Wiklund H., Nilsson K.;
RT   "Multiple myeloma cell lines.";
RL   (In) Human cell culture. Vol. 3. Cancer cell lines part 3; Masters J.R.W., Palsson B.O. (eds.); pp.81-155; Kluwer Academic Publishers; New York (2000).
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RX   PubMed=8062895; DOI=10.1111/j.1600-0609.1994.tb00176.x;
RA   Borset M., Waage A., Brekke O.L., Helseth E.;
RT   "TNF and IL-6 are potent growth factors for OH-2, a novel human
RT   myeloma cell line.";
RL   Eur. J. Haematol. 53:31-37(1994).
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RX   PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2;
RA   Drexler H.G., Matsuo Y.;
RT   "Malignant hematopoietic cell lines: in vitro models for the study of
RT   multiple myeloma and plasma cell leukemia.";
RL   Leuk. Res. 24:681-703(2000).
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RX   PubMed=11154231; DOI=10.1182/blood.V97.2.516;
RA   Hjertner O., Hjorth-Hansen H., Borset M., Seidel C., Waage A.,
RA   Sundan A.;
RT   "Bone morphogenetic protein-4 inhibits proliferation and induces
RT   apoptosis of multiple myeloma cells.";
RL   Blood 97:516-522(2001).
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RX   PubMed=32123307; DOI=10.1038/s41375-020-0785-1;
RA   Sarin V., Yu K., Ferguson I.D., Gugliemini O., Nix M.A., Hann B.,
RA   Sirota M., Wiita A.P.;
RT   "Evaluating the efficacy of multiple myeloma cell lines as models for
RT   patient tumors via transcriptomic correlation analysis.";
RL   Leukemia 34:2754-2765(2020).
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