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Cellosaurus VACO 4S (CVCL_5406)

[Text version]
Cell line name VACO 4S
Synonyms VACO-4S; VACO4S; Vaco4S
Accession CVCL_5406
Resource Identification Initiative To cite this cell line use: VACO 4S (RRID:CVCL_5406)
Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.
Doubling time: 30 hours (PubMed=6498841).
Microsatellite instability: Stable (MSS) (PubMed=24755471).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Rectum; UBERON=UBERON_0001052.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Ser1355fs*18 (c.4062_4066delTTCTT); Zygosity=Unspecified (PubMed=24755471).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Unspecified (PubMed=24755471).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Trp524Cys (c.1572G>T); ClinVar=VCV002147050; Zygosity=Unspecified (PubMed=24755471).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Asn239fs*1 (c.715_717AAC>T); Zygosity=Unspecified (PubMed=24755471).
Disease Rectal adenocarcinoma (NCIt: C9383)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_5405 ! VACO 4A
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
Publications

PubMed=6498841
John A. McBain, James L. Weese, Lorraine Faxon Meisner, William H. Wolberg, James K.V. Willson;
Establishment and characterization of human colorectal cancer cell lines.
Cancer Res. 44:5813-5821(1984)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028
Karin Bracht, Angela M. Nicholls, Ying Liu, Walter Fred Bodmer;
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=23272949; DOI=10.1186/1755-8794-5-66; PMCID=PMC3543849
Andreas Schlicker, Garry Beran, Christine M. Chresta, Gael McWalter, Alison Pritchard, Susie Weston, Sarah Runswick, Sara Davenport, Kerry Heathcote, Denis Alferez Castro, George Orphanides ...Show all 13 authors... , Tim French, Lodewyk F.A. Wessels; Show fewer authors
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
BMC Med. Genomics 5:66.1-66.15(2012)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Dmitri Mouradov, Clare Sloggett, Robert N. Jorissen, Christopher G. Love, Shan Li, Antony Wilks Burgess, Diego Arango, Robert L. Strausberg, Daniel Buchanan, Samuel Wormald, Liam O'Connor ...Show all 17 authors... , Jennifer L. Wilding, David C. Bicknell, Ian Philip Mark Tomlinson, Walter Fred Bodmer, John M. Mariadason, Oliver M. Sieber; Show fewer authors
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5406
ColonAtlas; VACO4S
Encyclopedic resources Wikidata; Q54992767
Gene expression databases GEO; GSM1346860
GEO; GSM1374982
Polymorphism and mutation databases Cosmic; 948849
Cosmic; 986023
Cosmic; 1043834
Cosmic; 2302024
Cosmic; 2760188
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number23