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Cellosaurus VACO 4A (CVCL_5405)

[Text version]
Cell line name VACO 4A
Synonyms Vaco 4A; VACO4A; Vaco4A
Accession CVCL_5405
Resource Identification Initiative To cite this cell line use: VACO 4A (RRID:CVCL_5405)
Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.
Doubling time: 30 hours (PubMed=6498841).
Omics: Proteomics.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Rectum; UBERON=UBERON_0001052.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Ser1355fs*18 (c.4062_4066delTTCTT); Zygosity=Unspecified (from autologous cell line VACO 4S).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Unspecified (from autologous cell line VACO 4S).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Trp524Cys (c.1572G>T); ClinVar=VCV002147050; Zygosity=Unspecified (from autologous cell line VACO 4S).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Asn239fs*1 (c.715_717AAC>T); Zygosity=Unspecified (PubMed=16418264).
HLA typing Source: PubMed=8464898
Class I
HLA-AA*01,03
Disease Rectal adenocarcinoma (NCIt: C9383)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_5406 ! VACO 4S
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
Web pages Info; Pawefish; -; https://www.cellosaurus.org/pawefish/ColonCellLineDescriptions/VACO4A.html
Publications

PubMed=6498841
John A. McBain, James L. Weese, Lorraine Faxon Meisner, William H. Wolberg, James K.V. Willson;
Establishment and characterization of human colorectal cancer cell lines.
Cancer Res. 44:5813-5821(1984)

PubMed=8464898; DOI=10.1073/pnas.90.7.2842; PMCID=PMC46192
Michael J. Browning, Peter Krausa, Andrew J. Rowan, David C. Bicknell, Julia Gwynaeth Bodmer, Walter Fred Bodmer;
Tissue typing the HLA-A locus from genomic DNA by sequence-specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines.
Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993)

PubMed=10737795; DOI=10.1073/pnas.97.7.3352; PMCID=PMC16243
Andrew J. Rowan, Hanan Lamlum, Mohammad Ilyas, James M.D. Wheeler, Jannes Straub, Angeliki Papadopoulou, David C. Bicknell, Walter Fred Bodmer, Ian Philip Mark Tomlinson;
APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'.
Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000)

PubMed=11226274; DOI=10.1073/pnas.041603298; PMCID=PMC30173
Wael M. Abdel-Rahman, Kanade Katsura, Willem Rens, Patricia A. Gorman, Denise Sheer, David C. Bicknell, Walter Fred Bodmer, Mark J. Arends, Andrew Hamilton Wyllie, Paul A.W. Edwards;
Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement.
Proc. Natl. Acad. Sci. U.S.A. 98:2538-2543(2001)

PubMed=16418264; DOI=10.1073/pnas.0510146103; PMCID=PMC1327731
Ying Liu, Walter Fred Bodmer;
Analysis of p53 mutations and their expression in 56 colorectal cancer cell lines.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006)

PubMed=18258742; DOI=10.1073/pnas.0712176105; PMCID=PMC2268141
Muhammad Emaduddin, David C. Bicknell, Walter Fred Bodmer, Stephan M. Feller;
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028
Karin Bracht, Angela M. Nicholls, Ying Liu, Walter Fred Bodmer;
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=23272949; DOI=10.1186/1755-8794-5-66; PMCID=PMC3543849
Andreas Schlicker, Garry Beran, Christine M. Chresta, Gael McWalter, Alison Pritchard, Susie Weston, Sarah Runswick, Sara Davenport, Kerry Heathcote, Denis Alferez Castro, George Orphanides ...Show all 13 authors... , Tim French, Lodewyk F.A. Wessels; Show fewer authors
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
BMC Med. Genomics 5:66.1-66.15(2012)

PubMed=29101300; DOI=10.15252/msb.20177701; PMCID=PMC5731344
Martin Frejno, Riccardo Zenezini Chiozzi, Mathias Wilhelm, Heiner Koch, Run-Sheng Zheng, Susan Klaeger, Benjamin Ruprecht, Chen Meng, Karl Kramer, Anna Jarzab, Stephanie Heinzlmeir ...Show all 20 authors... , Elaine Johnstone, Enric Domingo, David James Kerr, Moritz Jesinghaus, Julia Slotta-Huspenina, Wilko Weichert, Stefan Knapp, Stephan M. Feller, Bernhard Kuster; Show fewer authors
Pharmacoproteomic characterisation of human colon and rectal cancer.
Mol. Syst. Biol. 13:951-951(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5405
ColonAtlas; VACO4A
Encyclopedic resources Wikidata; Q54992765
Gene expression databases GEO; GSM1374981
Polymorphism and mutation databases Cosmic; 948843
Cosmic; 985654
Cosmic; 995404
Cosmic; 1043833
Cosmic; 1312321
Cosmic; 2760085
Cosmic; 2800593
IARC_TP53; 21758
Proteomic databases PRIDE; PXD005354
PRIDE; PXD005355
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number30