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Cellosaurus VACO 432 (CVCL_5402)

[Text version]
Cell line name VACO 432
Synonyms Vaco 432; VACO432; VaCo432; Vaco432; V432
Accession CVCL_5402
Resource Identification Initiative To cite this cell line use: VACO 432 (RRID:CVCL_5402)
Comments Microsatellite instability: Instable (MSI) (PubMed=25926053).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=25926053).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_A4IM (VACO 432 MAP2K1 (-/-))CVCL_A4IN (VACO 432 MAP2K2 (-/-))CVCL_LD57 (VACO 432 PIK3CA (H1047R/+))
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
STR profile Source(s): PubMed=25926053


Run an STR similarity search on this cell line

PubMed=7761852; DOI=10.1126/science.7761852
Markowitz S.D., Wang J., Myeroff L., Parsons R., Sun L., Lutterbaugh J.D., Fan R.S., Zborowska E., Kinzler K.W., Vogelstein B., Brattain M.G., Willson J.K.V.
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.
Science 268:1336-1338(1995)

PubMed=7816807; DOI=10.1073/pnas.92.1.151
Lisitsyn N.A., Lisitsina N.M., Dalbagni G., Barker P., Sanchez C.A., Gnarra J.R., Linehan W.M., Reid B.J., Wigler M.H.
Comparative genomic analysis of tumors: detection of DNA losses and amplification.
Proc. Natl. Acad. Sci. U.S.A. 92:151-155(1995)

Eshleman J.R., Lang E.Z., Bowerfind G.K., Parsons R., Vogelstein B., Willson J.K.V., Veigl M.L., Sedwick W.D., Markowitz S.D.
Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.
Oncogene 10:33-37(1995)

PubMed=8755562; DOI=10.1073/pnas.93.15.7832
Liu D., Pearlman E., Diaconu E., Guo K., Mori H., Haqqi T., Markowitz S.D., Willson J.K.V., Sy M.-S.
Expression of hyaluronidase by tumor cells induces angiogenesis in vivo.
Proc. Natl. Acad. Sci. U.S.A. 93:7832-7837(1996)

Sparks A.B., Morin P.J., Vogelstein B., Kinzler K.W.
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.
Cancer Res. 58:1130-1134(1998)

PubMed=11314036; DOI=10.1038/sj.onc.1204211
Forgacs E., Wren J.D., Kamibayashi C., Kondo M., Xu X.L., Markowitz S.D., Tomlinson G.E., Muller C.Y., Gazdar A.F., Garner H.R., Minna J.D.
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.
Oncogene 20:1005-1009(2001)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

Cell line databases/resources cancercelllines; CVCL_5402
Encyclopedic resources Wikidata; Q54992735
Gene expression databases GEO; GSM1448124
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number19